ArticleProceedings of the National Academy of Sciences of the United States of America2012
Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- A vascular-associated fibroblastic cell controls pancreatic islet immunity.Cell reports · 2025Article
- Lymph node stromal cells vary in susceptibility to infection but can support the intracellular growth of Listeria monocytogenes.Journal of leukocyte biology · 2024Article
- Distinct fibroblast functions associated with fibrotic and immune-mediated inflammatory diseases and their implications for therapeutic development.F1000Research · 2024Review
- Crosstalk between fibroblasts and T cells in immune networks.Frontiers in immunology · 2022Review
- Lymph Node Stromal Cell-Intrinsic MHC Class II Expression Promotes MHC Class I-Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Role of lymph node stroma and microenvironment in T cell tolerance.Immunological reviews · 2019Review
- Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.Toxicologic pathology · 2019Article
- IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response.European journal of immunology · 2019Article
- Impact of Chronic Viral Infection on T-Cell Dependent Humoral Immune Response.Frontiers in immunology · 2017Review
- TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo.Virology · 2016Article
- Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNα/β Defense Pathways.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Review
- Gut microbiota amplifies host-intrinsic conversion from the CD8 T cell lineage to CD4 T cells for induction of mucosal immune tolerance.Gut microbes · 2016Article
- Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L.Transplantation · 2015Article
- Lymph node fibroblastic reticular cells in health and disease.Nature reviews. Immunology · 2015Review
- Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications.Frontiers in immunology · 2015Review
- Early virus-host interactions dictate the course of a persistent infection.PLoS pathogens · 2015Article
- Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.The Journal of experimental medicine · 2014Article
- IFN-λ exerts opposing effects on T cell responses depending on the chronicity of the virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Networking at the level of host immunity: immune cell interactions during persistent viral infections.Cell host & microbe · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Fibroblastic reticular cells (FRCs) are lymphoid stromal cells essential to T-cell migration and survival. Although FRCs are targets of multiple viral infections, little is known about their role during infection due to the cells' scarcity and difficulty in isolating in vivo. To initiate studies of interactions among FRCs, viruses, and immune cells, we isolated and immortalized CD45(-)gp38(+)CD35(-)CD31(-)CD44(+)VCAM1(+) cell lines from C57BL/6 mice designated as immortalized FRC. Using these cloned cell lines, we have established that FRCs express the major histocompatibility complex (MHC) II molecule, a factor necessary for stimulation of CD4(+) T cells thought to be expressed primarily by antigen-presenting cells, along with other T-cell stimulatory ligands in an IFN-γ-dependent manner. In this environment, lymphocytic choriomeningitis virus (LCMV)-infected iFRCs activated naive LCMV-specific CD4(+) and CD8(+) T cells while limiting expansion of effector LCMV-specific T cells. Thus, FRCs effectively presented antigen along with activating signals during viral infection using both MHC I and MHC II molecules, illustrating a previously undescribed interaction with CD4(+) T cells and indicating a unique role for FRCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.