Evidence map›Paper›PMID 22550056›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2012

Peptides as targeting elements and tissue penetration devices for nanoparticles.

Erkki Ruoslahti

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 1 synthesis or guideline pooled it, 405 citations in OpenAlex.

  1. Systematic Review of Peptide CAQK: Properties, Applications, and Outcomes.International journal of molecular sciences · 2024
    Pooled it
  2. Article
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  6. Review
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  9. Review
  10. Formulation methods for peptide-modified lipid nanoparticles.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
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  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
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  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Erkki RuoslahtiCenter for Nanomedicine, UCSB, Biology II Bldg., University of California, Santa Barbara, CA 93106-9610, USA. ruoslahti@sanfordburnham.org
Sanford Burnham Prebys Medical Discovery Institute · US

Funding

Tumor Penetrating Peptides for Cancer TargetingR01CA152327 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI RUOSLAHTI, ERKKI · 2011 to 2015
$2.0M
NCI NIH HHS CA152327NCI NIH HHS R01 CA152327
6 · The paper itself

Abstract

The use of nanoparticles in medicine (nanomedicine) has recently become an intensely studied field. Nanoparticles carrying drugs and imaging agents have already reached the clinic, but they are essentially passive delivery vehicles, not what are referred to as "smart" nanoparticles. An important function to add to make nanoparticles smarter is active homing to the target tissue. It makes nanoparticles accumulate in the target tissue at higher concentrations than would be the case without this feature, increasing therapeutic efficacy and reducing side effects. This review discusses the recent developments in the nanoparticle targeting field with emphasis on peptides that home to vascular "zip codes" in target tissues and provide a tissue- and cell-penetrating function.

Indexed as

AnimalsBiocompatible MaterialsBiological Transport, ActiveDrug CarriersDrug Delivery SystemsHumansNanomedicineNanoparticlesNanotechnologyNeoplasmsPeptidesBiocompatible MaterialsDrug CarriersPeptides

Identifiers

PMID22550056
PMCPMC3947925
OpenAlexW2082575848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.