Evidence map›Paper›PMID 22549948›Full record

Trial reportCancer research2012

Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial.

Ikuyo Imayama, Cornelia M Ulrich, Catherine M Alfano, Chiachi Wang, Liren Xiao, Mark H Wener, Kristin L Campbell, Catherine Duggan, Karen E Foster-Schubert, Angela Kong and 6 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 8 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 8 syntheses or guidelines pooled it, 243 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Ikuyo ImayamaEpidemiology Program, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Cornelia M Ulrich
Catherine M Alfano
Chiachi Wang
Liren Xiao
Mark H Wener
Kristin L Campbell
Catherine Duggan
Karen E Foster-Schubert
Angela Kong
Caitlin E Mason
Ching-Yun Wang
George L Blackburn
Carolyn E Bain
Henry J Thompson
Anne McTiernan
University of Illinois Chicago · USUniversity of Washington · USFred Hutch Cancer Center · USGerman Cancer Research Center · DENational Cancer Institute · USNational Coalition for Cancer Survivorship · USColorado State University · USUniversity of British Columbia · CA

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE · 1986 to 2026
$30.4M
Preventing obesity in low income working adultsU54CA116847 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2005 to 2010
$12.6M
Institute for Translational Health Science (KL2)KL2RR025015 · NCRR · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2007 to 2011
$9.3M
UIC CANCER PREVENTION &CONTROL RESEARCH TRAINING GRANTR25CA057699 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FITZGIBBON, MARIAN L. · 1992 to 2017
$8.2M
Cancer Prevention Trng-Nutrition, Exercise &GeneticsR25CA094880 · NCI · UNIVERSITY OF WASHINGTON · PI WHITE, EMILY · 2002 to 2016
$7.3M
EXERCISE, DIET, AND SEX HORMONES IN POSTMENOPAUSAL WOMENR01CA105204 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MCTIERNAN, ANNE M. · 2004 to 2008
$3.3M
CIHRNCI NIH HHS 2R25CA057699NCI NIH HHS R01 CA105204NCI NIH HHS R01 CA105204-01A1NCI NIH HHS R25 CA057699NCI NIH HHS R25 CA094880NCI NIH HHS R25CA094880NCI NIH HHS U54 CA116847NCI NIH HHS U54-CA116847NCRR NIH HHS 5KL2RR025015-03NCRR NIH HHS KL2 RR025015NIDDK NIH HHS P30 DK035816PHS HHS 61-7015
6 · The paper itself

Abstract

Obese and sedentary persons have increased risk for cancer; inflammation is a hypothesized mechanism. We examined the effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in 439 women. Overweight and obese postmenopausal women were randomized to 1-year: caloric restriction diet (goal of 10% weight loss, N = 118), aerobic exercise (225 min/wk of moderate-to-vigorous activity, N = 117), combined diet + exercise (N = 117), or control (N = 87). Baseline and 1-year high-sensitivity C-reactive protein (hs-CRP), serum amyloid A (SAA), interleukin-6 (IL-6), leukocyte, and neutrophil levels were measured by investigators blind to group. Inflammatory biomarker changes were compared using generalized estimating equations. Models were adjusted for baseline body mass index (BMI), race/ethnicity, and age. Four hundred and thirty-eight (N = 1 in diet + exercise group was excluded) were analyzed. Relative to controls, hs-CRP decreased by geometric mean (95% confidence interval, P value): 0.92 mg/L (0.53-1.31, P < 0.001) in the diet and 0.87 mg/L (0.51-1.23, P < 0.0001) in the diet + exercise groups. IL-6 decreased by 0.34 pg/mL (0.13-0.55, P = 0.001) in the diet and 0.32 pg/mL (0.15-0.49, P < 0.001) in the diet + exercise groups. Neutrophil counts decreased by 0.31 × 10(9)/L (0.09-0.54, P = 0.006) in the diet and 0.30 × 10(9)/L (0.09-0.50, P = 0.005) in the diet + exercise groups. Diet and diet + exercise participants with 5% or more weight loss reduced inflammatory biomarkers (hs-CRP, SAA, and IL-6) compared with controls. The diet and diet + exercise groups reduced hs-CRP in all subgroups of baseline BMI, waist circumference, CRP level, and fasting glucose. Our findings indicate that a caloric restriction weight loss diet with or without exercise reduces biomarkers of inflammation in postmenopausal women, with potential clinical significance for cancer risk reduction.

Indexed as

Caloric RestrictionBiomarkersExerciseFemaleHumansInflammationInterleukin-6Leukocyte CountMiddle AgedNeutrophilsObesityOverweightPostmenopauseSerum Amyloid A ProteinWeight LossBiomarkersIL6 protein, humanInterleukin-6Serum Amyloid A Protein

Identifiers

PMID22549948
PMCPMC3342840
OpenAlexW2097813641

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.