ArticleThe Journal of biological chemistry2012
Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 47 citations in OpenAlex.
- The Evolving Portrait of γδ TCR Recognition Determinants.Journal of immunology (Baltimore, Md. : 1950) · 2024Review
- A close look at current γδ T-cell immunotherapy.Frontiers in immunology · 2023Review
- γδ T Cells in Brain Homeostasis and Diseases.Frontiers in immunology · 2022Review
- Our evolving understanding of the role of the γδ T cell receptor in γδ T cell mediated immunity.Biochemical Society transactions · 2021Review
- Ligand recognition by the γδ TCR and discrimination between homeostasis and stress conditions.Cellular & molecular immunology · 2020Review
- Natural Self-Ligand Gamma Delta T Cell Receptors (γδTCRs) Insight: The Potential of Induced IgG.Vaccines · 2020Article
- Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas.Nature communications · 2020Article
- An expanded parenchymal CD8+ T cell clone in GABAAnnals of clinical and translational neurology · 2020Article
- γδ TCR ligands: the quest to solve a 500-million-year-old mystery.Nature immunology · 2019Review
- The γδTCR combines innate immunity with adaptive immunity by utilizing spatially distinct regions for agonist selection and antigen responsiveness.Nature immunology · 2018Article
- Risk factors and disease mechanisms in myositis.Nature reviews. Rheumatology · 2018Review
- Vδ2Frontiers in immunology · 2018Review
- Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications.Frontiers in immunology · 2017Review
- Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy.Cancer letters · 2016Review
- The burgeoning family of unconventional T cells.Nature immunology · 2015Review
- The T cell antigen receptor: the Swiss army knife of the immune system.Clinical and experimental immunology · 2015Review
- Cytokines in immune-mediated inflammatory myopathies: cellular sources, multiple actions and therapeutic implications.Clinical and experimental immunology · 2014Review
- γδ T cell surveillance via CD1 molecules.Trends in immunology · 2014Review
- Article
- γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.Molecular immunology · 2014Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In polymyositis and inclusion body myositis, muscle fibers are surrounded and invaded by CD8-positive cytotoxic T cells expressing the αβ-T cell receptor (αβ-TCR) for antigen. In a rare variant of myositis, muscle fibers are similarly attacked by CD8-negative T cells expressing the γδ-TCR (γδ-T cell-mediated myositis). We investigated the antigen specificity of a human γδ-TCR previously identified in an autoimmune tissue lesion of γδ-T cell-mediated myositis. We show that this Vγ1.3Vδ2-TCR, termed M88, recognizes various proteins from different species. Several of these proteins belong to the translational apparatus, including some bacterial and human aminoacyl-tRNA synthetases (AA-RS). Specifically, M88 recognizes histidyl-tRNA synthetase, an antigen known to be also targeted by autoantibodies called anti-Jo-1. The M88 target epitope is strictly conformational, independent of post-translational modification, and exposed on the surface of the respective antigenic protein. Extensive mutagenesis of the translation initiation factor-1 from Escherichia coli (EcIF1), which served as a paradigm antigen with known structure, showed that a short α-helical loop around amino acids 39 to 42 of EcIF1 is a major part of the M88 epitope. Mutagenesis of M88 showed that the complementarity determining regions 3 of both γδ-TCR chains contribute to antigen recognition. M88 is the only known example of a molecularly characterized γδ-TCR expressed by autoaggressive T cells in tissue. The observation that AA-RS are targeted by a γδ-T cell and by autoantibodies reveals an unexpected link between T cell and antibody responses in autoimmune myositis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.