ArticleMolecular neurobiology2012
Integration of MicroRNA databases to study MicroRNAs associated with multiple sclerosis.
Article in Molecular neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 54 citations in OpenAlex.
- The gut microbiota-miRNA axis in multiple sclerosis: Mechanisms and therapeutic potentials.Folia microbiologica · 2026Review
- Exploring the theranostic potentials of miRNA and epigenetic networks in autoimmune diseases: A comprehensive review.Immunity, inflammation and disease · 2023Review
- Cladribine and ocrelizumab induce differential miRNA profiles in peripheral blood mononucleated cells from relapsing-remitting multiple sclerosis patients.Frontiers in immunology · 2023Article
- Development and validation of a genomic nomogram based on a ceRNA network for comprehensive analysis of obstructive sleep apnea.Frontiers in genetics · 2023Article
- Review
- Article
- MiR-142-3p regulates synaptopathy-driven disease progression in multiple sclerosis.Neuropathology and applied neurobiology · 2022Observational
- MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression.Neural regeneration research · 2020Review
- MicroRNA-20a-5p Ameliorates Non-alcoholic Fatty Liver Disease via Inhibiting the Expression of CD36.Frontiers in cell and developmental biology · 2020Article
- Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas.Frontiers in bioengineering and biotechnology · 2019Article
- Transcriptome profiling of peripheral blood immune cell populations in multiple sclerosis patients before and during treatment with a sphingosine-1-phosphate receptor modulator.CNS neuroscience & therapeutics · 2018Article
- miR-142-3p Is a Key Regulator of IL-1β-Dependent Synaptopathy in Neuroinflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Biomarkers of multiple sclerosis: current findings.Degenerative neurological and neuromuscular disease · 2017Review
- Analysis of microRNA and Gene Expression Profiles in Multiple Sclerosis: Integrating Interaction Data to Uncover Regulatory Mechanisms.Scientific reports · 2016Article
- Comprehensive evaluation of serum microRNAs as biomarkers in multiple sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2016Article
- MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.Journal of cellular and molecular medicine · 2016Article
- Dicer and microRNA expression in multiple sclerosis and response to interferon therapy.Journal of neuroimmunology · 2016Article
- Post-transcriptional Regulation of BRCA2 through Interactions with miR-19a and miR-19b.Frontiers in genetics · 2016Article
- MicroRNAs in neuronal communication.Molecular neurobiology · 2014Review
- Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis.Genome medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs which regulate many genes post-transcriptionally. In various contexts of medical science, miRNAs gained increasing attention over the last few years. Analyzing the functions, interactions and cellular effects of miRNAs is a very complex and challenging task. Many miRNA databases with diverse data contents have been developed. Here, we demonstrate how to integrate their information in a reasonable way on a set of miRNAs that were found to be dysregulated in the blood of patients with multiple sclerosis (MS). Using the miR2Disease database, we retrieved 16 miRNAs associated with MS according to four different studies. We studied the predicted and experimentally validated target genes of these miRNAs, their expression profiles in different blood cell types and brain tissues, the pathways and biological processes affected by these miRNAs as well as their regulation by transcription factors. Only miRNA-mRNA interactions that were predicted by at least seven different prediction algorithms were considered. This resulted in a network of 1,498 target genes. In this network, the MS-associated miRNAs hsa-miR-20a-5p and hsa-miR-20b-5p occurred as central hubs regulating about 500 genes each. Strikingly, many of the putative target genes play a role in T cell activation and signaling, and many have transcription factor activity. The latter suggests that miRNAs often act as regulators of regulators with many secondary effects on gene expression. Our present work provides a guideline on how information of different databases can be integrated in the analysis of miRNAs. Future investigations of miRNAs shall help to better understand the mechanisms underlying different diseases and their treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.