ArticleMucosal immunology2012
Altered regulation of Toll-like receptor responses impairs antibacterial immunity in the allergic lung.
Article in Mucosal immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 66 citations in OpenAlex.
- Nasal Lipopolysaccharide Challenge and Cytokine Measurement Reflects Innate Mucosal Immune Responsiveness.PloS one · 2015Trial
- Atopic conditions other than asthma and risk of the 2009 novel H1N1 infection in children: a case-control study.Allergy and asthma proceedingsTrial
- Contributions of maternal prenatal infection and antibiotic exposure to offspring infection and risk for allergic respiratory conditions through age 5.Brain, behavior, & immunity - health · 2024Article
- Bone Formation and Maintenance in Oral Surgery: The Decisive Role of the Immune System-A Narrative Review of Mechanisms and Solutions.Bioengineering (Basel, Switzerland) · 2024Review
- Trained immunity in type 2 immune responses.Mucosal immunology · 2022Review
- Risk of pneumonia in asthmatic children using inhaled corticosteroids: a nested case-control study in a birth cohort.BMJ open · 2022Article
- Impact of Therapeutics on Unified Immunity During Allergic Asthma and Respiratory Infections.Frontiers in allergy · 2022Review
- House Dust Mite Aeroallergen Suppresses Leukocyte Phagocytosis and Netosis Initiated by Pneumococcal Lung Infection.Frontiers in pharmacology · 2022Article
- Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle.American journal of respiratory cell and molecular biology · 2021Review
- Selective IgA Deficiency a Probable Risk of Recurrent Chest Infections in Asthmatics.Journal of asthma and allergy · 2021Article
- Asthma and COVID-19: Emphasis on Adequate Asthma Control.Canadian respiratory journal · 2021Review
- Transcriptomic analysis reveals diverse gene expression changes in airway macrophages during experimental allergic airway disease.Wellcome open research · 2020Article
- Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice.Innate immunity · 2019Article
- THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.Scientific reports · 2017Article
- Increased TREM-2 expression on the subsets of CD11cScientific reports · 2017Article
- Article
- Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.BMC immunology · 2016Article
- Asthma as a risk factor for zoster in adults: A population-based case-control study.The Journal of allergy and clinical immunology · 2016Article
- Toll-like receptors, triggering receptor expressed on myeloid cells family members and receptor for advanced glycation end-products in allergic airway inflammation.Expert review of respiratory medicine · 2016Review
- Macrophage adaptation in airway inflammatory resolution.European respiratory review : an official journal of the European Respiratory Society · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
The lung is colonized by commensal bacteria, some of which are associated with asthma exacerbations. Using the intranasal house-dust mite-sensitized mouse model of allergic airway disease, we show an imbalance in novel antibacterial pathways that culminates in a reduction in neutrophil recruitment to the airspaces and leads to bacterial invasion and dissemination. The expression of TREM (Triggering Receptor Expressed on Myeloid cells)-1 that amplifies Toll-like receptor (TLR) signaling and TREM-2 that inhibits this process is reversed. Furthermore, endogenous TLR inhibitors (A20, Tollip, SOCS1, and IRAK-M) and proteins involved in receptor recycling (TRIAD3) are raised. Consequently, the production of neutrophil chemoattractants is reduced. Intranasal administration of either chemokine restores the ability to recruit neutrophils, which prevents bacterial invasion. A background of allergic airway disease therefore exacerbates bacterial infection by altering key antibacterial innate immune pathways that are amenable to therapeutic intervention.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.