ArticleJournal of exposure science & environmental epidemiology2012
Polycyclic aromatic hydrocarbon exposure and wheeze in a cohort of children with asthma in Fresno, CA.
Article in Journal of exposure science & environmental epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 85 citations in OpenAlex.
- Childhood exposure to ambient polycyclic aromatic hydrocarbons is linked to epigenetic modifications and impaired systemic immunity in T cells.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2015Trial
- Ambient air toxics and asthma prevalence among a representative sample of US kindergarten-age children.PloS one · 2013Trial
- Host mScientific reports · 2026Article
- Article
- Susceptibility to childhood asthma modified by the interactive effects of polycyclic aromatic hydrocarbons exposure and genetic polymorphisms of the aryl hydrocarbon receptor signaling pathway: functional analysis based on lipid metabolism.Respiratory research · 2025Article
- Epigenetic Alterations in PAH-Induced Childhood Asthma: An Intervention Using Sulforaphane.Toxics · 2025Article
- Associations of environmental chemical exposures measured in personal silicone wristbands with sociodemographic factors, COVID-19 restrictions, and child respiratory health.Environmental research · 2024Article
- Urinary biomarkers of environmental exposures and asthma morbidity in a school inner city asthma study.International journal of hygiene and environmental health · 2024Article
- Association of chronic cough with exposure to polycyclic aromatic hydrocarbons in the US population.Heliyon · 2024Article
- Asthma and Environmental Exposures to Phenols, Polycyclic Aromatic Hydrocarbons, and Phthalates in Children.Current environmental health reports · 2023Article
- The impact of the 2019/2020 Australian landscape fires on infant feeding and contaminants in breast milk in women with asthma.International breastfeeding journal · 2023Article
- Maternal exposure to urinary polycyclic aromatic hydrocarbons (PAH) in pregnancy and childhood asthma in a pooled multi-cohort study.Environment international · 2022Article
- Effects of Polycyclic Aromatic Hydrocarbons on Lung Function in Children with Asthma: A Mediation Analysis.International journal of environmental research and public health · 2022Article
- The preliminary investigation of potential response biomarkers to PAHs exposure on childhood asthma.Journal of exposure science & environmental epidemiology · 2022Article
- Systematic Review of Exposure to Polycyclic Aromatic Hydrocarbons and Obstructive Lung Disease.Journal of health & pollution · 2021Review
- Polycyclic Aromatic Hydrocarbon Levels in Wistar Rats Exposed to Ambient Air of Port Harcourt, Nigeria: An Indicator for Tissue Toxicity.International journal of environmental research and public health · 2021Article
- Assessing Approaches of Human Inhalation Exposure to Polycyclic Aromatic Hydrocarbons: A Review.International journal of environmental research and public health · 2021Review
- Model choice for estimating the association between exposure to chemical mixtures and health outcomes: A simulation study.PloS one · 2021Article
- Decrease in Ambient Polycyclic Aromatic Hydrocarbon Concentrations in California's San Joaquin Valley 2000-2019.Atmospheric environment (Oxford, England : 1994) · 2020Article
- Potential role of polycyclic aromatic hydrocarbons in air pollution-induced non-malignant respiratory diseases.Respiratory research · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are found widely in the ambient air and result from combustion of various fuels and industrial processes. PAHs have been associated with adverse human health effects such as cognitive development, childhood IQ, and respiratory health. The Fresno Asthmatic Children's Environment Study enrolled 315 children aged 6-11 years with asthma in Fresno, CA and followed the cohort from 2000 to 2008. Subjects were evaluated for asthma symptoms in up to three 14-day panels per year. Detailed ambient pollutant concentrations were collected from a central site and outdoor pollutants were measured at 83 homes for at least one 5-day period. Measurements of particle-bound PAHs were used with land-use regression models to estimate individual exposures to PAHs with 4-, 5-, or 6-member rings (PAH456) and phenanthrene for the cohort (approximately 22,000 individual daily estimates). We used a cross-validation-based algorithm for model fitting and a generalized estimated equation approach to account for repeated measures. Multiple lags and moving averages of PAH exposure were associated with increased wheeze for each of the three types of PAH exposure estimates. The odds ratios for asthmatics exposed to PAHs (ng/m(3)) ranged from 1.01 (95% CI, 1.00-1.02) to 1.10 (95% CI, 1.04-1.17). This trend for increased wheeze persisted among all PAHs measured. Phenanthrene was found to have a higher relative impact on wheeze. These data provide further evidence that PAHs contribute to asthma morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.