ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging.Frontiers in aging neuroscience · 2022Pooled it
- Cerebral blood flow as a biomarker of resilience in cognitively unimpaired APOE ɛ4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- The physiological effects of APOE genotype in healthy young/middle-aged individuals.Biological reviews of the Cambridge Philosophical Society · 2026Article
- Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers.GeroScience · 2025Article
- Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.Neurobiology of aging · 2025Article
- Cerebral perfusion and amyloidosis in the oldest-old.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cellular and molecular mechanisms of the blood-brain barrier dysfunction in neurodegenerative diseases.Fluids and barriers of the CNS · 2024Review
- Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy.Molecular neurodegeneration · 2023Article
- The Utility of Arterial Spin Labeling MRI in Medial Temporal Lobe as a Vascular Biomarker in Alzheimer's Disease Spectrum: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2022Review
- Differential Effects of APOE Genotype on MicroRNA Cargo of Cerebrospinal Fluid Extracellular Vesicles in Females With Alzheimer's Disease Compared to Males.Frontiers in cell and developmental biology · 2022Article
- Mediation of the APOE Associations With Cognition Through Cerebral Blood Flow: The CIBL Study.Frontiers in aging neuroscience · 2022Article
- Cerebral blood flow changes during aging process and in cognitive disorders: A review.The neuroradiology journal · 2021Review
- Lower cerebral perfusion is associated with tau-PET in the entorhinal cortex across the Alzheimer's continuum.Neurobiology of aging · 2021Article
- Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood Flow.Frontiers in physiology · 2021Review
- Relationship Between Cerebrovascular Reactivity and Cognition Among People With Risk of Cognitive Decline.Frontiers in physiology · 2021Article
- Entorhinal Perfusion Predicts Future Memory Decline, Neurodegeneration, and White Matter Hyperintensity Progression in Older Adults.Journal of Alzheimer's disease : JAD · 2021Article
- Hemodynamic latency is associated with reduced intelligence across the lifespan: an fMRI DCM study of aging, cerebrovascular integrity, and cognitive ability.Brain structure & function · 2020Article
- Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.Brain imaging and behavior · 2020Article
- Brain hemodynamic changes in amnestic mild cognitive impairment measured by pulsed arterial spin labeling.Aging · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Using whole-brain pulsed arterial spin labeling magnetic resonance imaging, resting cerebral blood flow (CBF) was measured in 20 mild cognitive impairment (MCI; 11 ɛ3 and 9 ɛ4) and 40 demographically matched cognitively normal (CN; 27 ɛ3 and 13 ɛ4) participants. An interaction of apolipoprotein (APOE) genotype (ɛ3 and ɛ4) and cognitive status (CN and MCI) on quantified gray-matter CBF corrected for partial volume effects was found in the left parahippocampal and fusiform gyri (PHG/FG), right middle frontal gyrus, and left medial frontal gyrus. In the PHG/FG, CBF was elevated for CN ɛ4 carriers but decreased for MCI ɛ4 carriers. The opposite pattern was seen in frontal regions: CBF was decreased for CN ɛ4 carriers but increased for MCI ɛ4 carriers. Cerebral blood flow in the PHG/FG was positively correlated with verbal memory for CN ɛ4 adults (r=0.67, P=0.01). Cerebral blood flow in the left medial frontal gyrus was positively correlated with verbal memory for MCI ɛ4 adults (r=0.70, P=0.05). Findings support dynamic pathophysiologic processes in the brain associated with Alzheimer's disease risk and indicate that cognitive status and APOE genotype have interactive effects on CBF. Correlations between CBF and verbal memory suggest a differential neurovascular compensatory response in posterior and anterior cortices with cognitive decline in ɛ4 adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.