ReviewProtein & cell2012
Epigenetic control on cell fate choice in neural stem cells.
Review in Protein & cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Interaction between N6-methyladenosine (mGenes & diseases · 2026Review
- 3D Genome Architecture in Stem Cell Lineage Commitment: from Structural Organization to Precision Regulation.Advanced genetics (Hoboken, N.J.) · 2025Review
- Emerging Functional Connections Between Metabolism and Epigenetic Remodeling in Neural Differentiation.Molecular neurobiology · 2024Review
- ATRX guards against aberrant differentiation in mesenchymal progenitor cells.Nucleic acids research · 2024Article
- Tcf12 and NeuroD1 cooperatively drive neuronal migration during cortical development.Development (Cambridge, England) · 2022Article
- HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation.Epigenetics · 2021Article
- Satellite Glial Cells Give Rise to Nociceptive Sensory Neurons.Stem cell reviews and reports · 2021Article
- Article
- Unique and Specific mGenes · 2020Article
- Programmed Epigenetic DNA Methylation-Mediated Reduced Neuroprogenitor Cell Proliferation and Differentiation in Small-for-Gestational-Age Offspring.Neuroscience · 2019Article
- Harnessing the HDAC-histone deacetylase enzymes, inhibitors and how these can be utilised in tissue engineering.International journal of oral science · 2019Review
- Identification of bioactive metabolites using activity metabolomics.Nature reviews. Molecular cell biology · 2019Review
- METTL3-mediated m6A modification is required for cerebellar development.PLoS biology · 2018Article
- Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity.Genome research · 2015Article
- The epigenetics of aging and neurodegeneration.Progress in neurobiology · 2015Review
- Transcriptional regulator PRDM12 is essential for human pain perception.Nature genetics · 2015Article
- Reconciling competence and transcriptional hierarchies with stochasticity in retinal lineages.Current opinion in neurobiology · 2014Review
- Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease.Molecular neurodegeneration · 2014Review
- Mobilizing endogenous stem cells for retinal repair.Translational research : the journal of laboratory and clinical medicine · 2014Review
- Shifts in the vascular endothelial growth factor isoforms result in transcriptome changes correlated with early neural stem cell proliferation and differentiation in mouse forebrain.Developmental neurobiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Derived from neural stem cells (NSCs) and progenitor cells originated from the neuroectoderm, the nervous system presents an unprecedented degree of cellular diversity, interwoven to ensure correct connections for propagating information and responding to environmental cues. NSCs and progenitor cells must integrate cell-intrinsic programs and environmental cues to achieve production of appropriate types of neurons and glia at appropriate times and places during development. These developmental dynamics are reflected in changes in gene expression, which is regulated by transcription factors and at the epigenetic level. From early commitment of neural lineage to functional plasticity in terminal differentiated neurons, epigenetic regulation is involved in every step of neural development. Here we focus on the recent advance in our understanding of epigenetic regulation on orderly generation of diverse neural cell types in the mammalian nervous system, an important aspect of neural development and regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.