Evidence map›Paper›PMID 22549499›Full record

ArticleTherapeutic drug monitoring2012

High dose of darunavir in treatment-experienced HIV-infected adolescent results in virologic suppression and improved CD4 cell count.

Natella Y Rakhmanina, Michael N Neely, Edmund V Capparelli

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic drug monitoring, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. A review of the toxicity of HIV medications.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2014
    Review
  3. Article
  4. Pharmacotherapy of pediatric HIV infection.Pediatric clinics of North America · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natella Y RakhmaninaDivision of Infectious Diseases, Department of Pediatrics, Children's National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC 20010, USA. nrakhman@cnmc.org
Michael N Neely
Edmund V Capparelli

Funding

International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) GroupU01AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI JACKSON, J BROOKS · 2006 to 2010
$109.7M
Populaton Pharmacokinetic Modeling and Optimal ControlR01GM068968 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEELY, MICHAEL N. · 2003 to 2015
$3.9M
TRAINING & OUTREACH COREU54HD071600 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAPPARELLI, EDMUND VINCENT · 2011 to 2015
$3.6M
Optimizing Coordinated Combination Drug TherapyR01EB005803 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JELLIFFE, ROGER W. · 2006 to 2009
$2.2M
Effect of Puberty on the Phamacokinetics of Efavirenz in HIV-infected ChildrenK23HD060452 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI RAKHMANINA, NATELLA YURIEVNA · 2009 to 2012
$498k
Plasma and Genital HIV Dynamics in WomenK23AI076106 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NEELY, MICHAEL N. · 2007 to 2010
$466k
NIAID NIH HHS K23 AI076106NIAID NIH HHS K23AI076106NIAID NIH HHS U01 AI068632NIAID NIH HHS U01 AI 68632NIBIB NIH HHS R01 EB005803NICHD NIH HHS 1U54HD071600-01NICHD NIH HHS K23 1K23HD060452NICHD NIH HHS K23 HD060452NICHD NIH HHS U54 HD071600NIGMS NIH HHS R01 GM068968
6 · The paper itself

Abstract

We describe an unintentional significant overdose of darunavir in a treatment-experienced adolescent with decreased darunavir susceptibility and prior treatment failure on darunavir therapy. Minimal toxicity and improved virologic suppression observed with an overdose have prompted consideration of the continued use of a higher than recommended dose. Pharmacokinetic and pharmacodynamic evaluations justified the individualized use of high-dose darunavir, which resulted in virologic suppression, improved CD4 cell count, and resolution of toxicity.

Indexed as

HIV-1Prescription Drug MisuseCD4 Lymphocyte CountChildDarunavirHIV InfectionsHIV Protease InhibitorsHumansMaleSulfonamidesTreatment OutcomeViral LoadDarunavirHIV Protease InhibitorsSulfonamides

Identifiers

PMID22549499
PMCPMC3354040

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.