ArticleEuropean journal of human genetics : EJHG2012
Community of protein complexes impacts disease association.
Article in European journal of human genetics : EJHG, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Integration of protein sequence and protein-protein interaction data by hypergraph learning to identify novel protein complexes.Briefings in bioinformatics · 2024Article
- Exploring novel disease-disease associations based on multi-view fusion network.Computational and structural biotechnology journal · 2023Article
- TSMDA: Target and symptom-based computational model for miRNA-disease-association prediction.Molecular therapy. Nucleic acids · 2021Article
- Lung disease network reveals impact of comorbidity on SARS-CoV-2 infection and opportunities of drug repurposing.BMC medical genomics · 2021Article
- Article
- Reforming disease classification system-are we there yet?Annals of translational medicine · 2018Article
- Network spectra for drug-target identification in complex diseases: new guns against old foes.Applied network science · 2018Review
- HGPEC: a Cytoscape app for prediction of novel disease-gene and disease-disease associations and evidence collection based on a random walk on heterogeneous network.BMC systems biology · 2017Article
- Understanding cancer complexome using networks, spectral graph theory and multilayer framework.Scientific reports · 2017Article
- Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes.BMC medical genomics · 2017Article
- Biomechanisms of Comorbidity: Reviewing Integrative Analyses of Multi-omics Datasets and Electronic Health Records.Yearbook of medical informatics · 2016Review
- A novel method for identifying disease associated protein complexes based on functional similarity protein complex networks.Algorithms for molecular biology : AMB · 2015Article
- Dissecting the Characteristics and Dynamics of Human Protein Complexes at Transcriptome Cascade Using RNA-Seq Data.PloS one · 2013Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
One important challenge in the post-genomic era is uncovering the relationships among distinct pathophenotypes by using molecular signatures. Given the complex functional interdependencies between cellular components, a disease is seldom the consequence of a defect in a single gene product, instead reflecting the perturbations of a group of closely related gene products that carry out specific functions together. Therefore, it is meaningful to explore how the community of protein complexes impacts disease associations. Here, by integrating a large amount of information from protein complexes and the cellular basis of diseases, we built a human disease network in which two diseases are linked if they share common disease-related protein complex. A systemic analysis revealed that linked disease pairs exhibit higher comorbidity than those that have no links, and that the stronger association two diseases have based on protein complexes, the higher comorbidity they are prone to display. Moreover, more connected diseases tend to be malignant, which have high prevalence. We provide novel disease associations that cannot be identified through previous analysis. These findings will potentially provide biologists and clinicians new insights into the etiology, classification and treatment of diseases.
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