Evidence map›Paper›PMID 22548895›Full record

SynthesisBipolar disorders2012

Meta-analysis of the association between cognitive abilities and everyday functioning in bipolar disorder.

Colin A Depp, Brent T Mausbach, Alexandrea L Harmell, Gauri N Savla, Christopher R Bowie, Philip D Harvey, Thomas L Patterson

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Bipolar disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 8 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 8 syntheses or guidelines pooled it, 340 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Bipolar disorder in oncology: Considerations for the psychiatrist.Journal of mood and anxiety disorders · 2026
    Review
  20. Review

67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Colin A DeppDepartment of Psychiatry, University of California, San Diego, La Jolla, CA 92093-0603, USA. cdepp@ucsd.edu
Brent T Mausbach
Alexandrea L Harmell
Gauri N Savla
Christopher R Bowie
Philip D Harvey
Thomas L Patterson
University of California, San Diego · USQueen's University · CAUniversity of Miami · US

Funding

IMPLEMENTATION RESEARCH INSTITUTE FOR MENTAL HEALTH SERVICES IRI-MHSR25MH080916 · NIMH · WASHINGTON UNIVERSITY · PI Byron James Powell · 2009 to 2026
$3.7M
Skills Training and Empowerment Program for Middle-Aged and Older Patients with PR01MH084967 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAUSBACH, BRENT T · 2009 to 2013
$2.8M
Validating Assessments of Real-World OutcomeR01MH078737 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PATTERSON, THOMAS L. · 2007 to 2011
$1.7M
Validation of Measures of real-world outcomeR01MH078775 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARVEY, PHILIP D. · 2007 to 2011
$1.7M
A Medication Adherence Intervention for Older Adults with Bipolar DisorderK23MH077225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2007 to 2011
$763k
Development of a Personalized Real-Time Intervention for Bipolar DisorderR34MH091260 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2010 to 2012
$691k
NIMH NIH HHS K23 MH077225NIMH NIH HHS MH077225NIMH NIH HHS MH 078775NIMH NIH HHS MH084967NIMH NIH HHS MH091260NIMH NIH HHS R01 MH078737NIMH NIH HHS R01 MH078775NIMH NIH HHS R01 MH084967NIMH NIH HHS R25 MH080916NIMH NIH HHS R34 MH091260
6 · The paper itself

Abstract

objectivesNeurocognitive deficits are common in bipolar disorder and contribute to functional disability. However, the degree to which general and specific cognitive deficits affect everyday functioning in bipolar disorder is unknown. The goal of this meta-analysis was to examine the magnitude of the effect of specific neurocognitive abilities on everyday functioning in bipolar disorder.

methodsWe conducted a comprehensive meta-analysis of studies that reported associations between performance on objective neuropsychological tasks and everyday functioning among individuals with bipolar disorder. From an initial pool of 486 papers, 22 studies met inclusion criteria, comprising a total of 1344 participants. Correlation coefficients were calculated for 11 cognitive domains and four measurement modalities for functioning. We also examined effect moderators, such as sample age, clinical state, and study design.

resultsThe mean Pearson correlation between neurocognitive ability and functioning was 0.27, and was significant for all cognitive domains and varied little by cognitive domain. Correlations varied by methods of everyday functioning assessment, being lower for clinician and self-report than performance-based tasks and real-world milestones such as employment. None of the moderator analyses were significant.

conclusionsOverall, the strength of association between cognitive ability and everyday functioning in bipolar disorder is strikingly similar to that seen in schizophrenia, with little evidence for differences across cognitive domains. The strength of association differed to a greater extent according to functional measurement approach.

Indexed as

Activities of Daily LivingBipolar DisorderCognition DisordersDatabases, BibliographicHumansNeuropsychological TestsPsychiatric Status Rating ScalesStatistics as Topic

Identifiers

PMID22548895
PMCPMC3396289
OpenAlexW2146170358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.