ReviewSeminars in cancer biology2012
The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells.
Review in Seminars in cancer biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Identification of a prognostic index system and tumor immune infiltration characterization for lung adenocarcinoma based on mRNA molecular of pyroptosis.Frontiers in medicine · 2022Article
- Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis.Seminars in cancer biology · 2022Review
- Cancer Stem Cells in the Immune Microenvironment.Advances in experimental medicine and biology · 2021Article
- Regulatory Role of Quiescence in the Biological Function of Cancer Stem Cells.Stem cell reviews and reports · 2020Review
- Epithelial-to-mesenchymal transition and cancer stem cells contribute to breast cancer heterogeneity.Journal of cellular physiology · 2018Review
- New Insights into the Tumor Microenvironment Utilizing Protein Array Technology.International journal of molecular sciences · 2018Review
- Nanotechniques Inactivate Cancer Stem Cells.Nanoscale research letters · 2017Article
- Tumor microenvironment heterogeneity: challenges and opportunities.Current molecular biology reports · 2017Article
- Breast cancer stem cell: the roles and therapeutic implications.Cellular and molecular life sciences : CMLS · 2017Review
- Targeting Cancer Stem Cells-A Renewed Therapeutic Paradigm.Oncology & hematology review · 2017Article
- Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesis.Oncogene · 2016Article
- Stem cell technology in breast cancer: current status and potential applications.Stem cells and cloning : advances and applications · 2016Review
- [Advances in Lung Stem Cells and Lung Cancer Stem Cells].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Review
- Lung carcinogenesis from chronic obstructive pulmonary disease: characteristics of lung cancer from COPD and contribution of signal transducers and lung stem cells in the inflammatory microenvironment.General thoracic and cardiovascular surgery · 2014Review
- Cancer stem cells: a systems biology view of their role in prognosis and therapy.Anti-cancer drugs · 2014Review
- Evolving concepts of tumor heterogeneity.Cell & bioscience · 2014Review
- Far beyond the usual biomarkers in breast cancer: a review.Journal of Cancer · 2014Review
- "Just caring": can we afford the ethical and economic costs of circumventing cancer drug resistance?Journal of personalized medicine · 2013Article
- IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation.Molecular cancer · 2012Article
- Detection of Putative Stem-cell Markers in Invasive Ductal Carcinoma of the Breast by Immunohistochemistry: Does It Improve Prognostic/Predictive Assessments?Applied immunohistochemistry & molecular morphology : AIMMArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Tumors have been increasingly recognized as organs with a complexity that approaches, and may even exceed, that of healthy tissues. When viewed from this perspective, the biology of a tumor can be understood only by studying tumor cell heterogeneity and the microenvironment that is constructed during the course of tumorigenesis and malignant progression. Recent work has revealed the existence of cancer stem cells, the "bugs", with the capacity for self-renewal and tumor propagation. In addition, it is now recognized that the tumor microenvironment, the "bed", plays a critical role in supporting cancer stem cells and also may promote neoplasia and malignant progression. The interdependence of the cell-intrinsic features of cancer, including the cancer stem cell "bugs" and the tumor microenvironment "bed", is only beginning to be understood. In this review, we highlight the rapidly evolving concepts about the interactions between tumor stem cells and their microenvironment, the insights gained from studying their normal tissue counterparts, and the questions and controversies surrounding this area of research, with an emphasis on breast and lung cancer. Finally, we address evidence supporting the notion that eliminating the bed as well as the bugs should lead to more effective and personalized cancer treatments that improve patient outcome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.