ArticleAnalytical chemistry2012
Direct measurement of glyconanoparticles and lectin interactions by isothermal titration calorimetry.
Article in Analytical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- A universal strategy of glyconanoparticle preparation using a bifunctional linker for lectin sensing and cell imaging.Mikrochimica acta · 2022Article
- From structure to function - Ligand recognition by myeloid C-type lectin receptors.Computational and structural biotechnology journal · 2022Review
- Quantification of binding affinity of glyconanomaterials with lectins.Chemical communications (Cambridge, England) · 2020Review
- Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites.RSC advances · 2020Article
- Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media.Nanomaterials (Basel, Switzerland) · 2019Article
- Electrochemical Impedance Spectroscopy Study of Concanavalin A Binding to Self-Assembled Monolayers of Mannosides on Gold Wire Electrodes.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2016Article
- Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.Advanced healthcare materials · 2016Article
- Glyconanomaterials for biosensing applications.Biosensors & bioelectronics · 2016Review
- Carbohydrate-Conjugated Hollow Oblate Mesoporous Silica Nanoparticles as Nanoantibiotics to Target Mycobacteria.Advanced healthcare materials · 2015Article
- Studies of Highly-Ordered Heterodiantennary Mannose/Glucose-Functionalized Polymers and Concanavalin A Protein Interactions Using Isothermal Titration Calorimetry.Biomacromolecules · 2015Article
- Glyconanomaterials for Combating Bacterial Infections.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Selective targeting of Mycobacterium smegmatis with trehalose-functionalized nanoparticles.Chemical communications (Cambridge, England) · 2015Article
- Lectin-gated, mesoporous, photofunctionalized glyconanoparticles for glutathione-responsive drug delivery.Chemical communications (Cambridge, England) · 2015Article
- Glycodendrimers and Modified ELISAs: Tools to Elucidate Multivalent Interactions of Galectins 1 and 3.Molecules (Basel, Switzerland) · 2015Article
- Synthesis of multifunctional cellulose nanocrystals for lectin recognition and bacterial imaging.Biomacromolecules · 2015Article
- Characterization of the Grp94/OS-9 chaperone-lectin complex.Journal of molecular biology · 2014Article
- Glyconanomaterials: Emerging applications in biomedical research.Nano research · 2014Article
- Influence of ligand presentation density on the molecular recognition of mannose-functionalised glyconanoparticles by bacterial lectin BC2L-A.Glycoconjugate journal · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Glyconanomaterials have shown high potential in applications including bioanalysis and nanomedicine. Here, a quantitative analytical technique, based on isothermal titration calorimetry, was developed to characterize the interactions between glyconanoparticles and lectins. By titrating lectins into the glyconanoparticle solution, the apparent dissociation constant, thermodynamic parameters, and the number of binding sites were derived simultaneously. For the glyconanoparticles-lectin binding pairs investigated, a 3-5 order of magnitude affinity enhancement over the free ligand-lectin interactions was observed which can be attributed to the multivalent ligand presentation on the nanoparticles. The impact of ligand density was also studied, and results showed that the affinity increased with the number of glycans on the nanoparticle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.