ArticleJournal of neurochemistry2012
Domain-dependent effects of DAT inhibition in the rat dorsal striatum.
Article in Journal of neurochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing.Biosensors · 2025Review
- Batch-fabricated full glassy carbon fibers for real-time tonic and phasic dopamine detection.Frontiers in bioengineering and biotechnology · 2025Article
- Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry.ACS omega · 2024Article
- Accurate and stable chroniciScience · 2022Article
- Flexible Glassy Carbon Multielectrode Array forBiosensors · 2022Article
- In vivo evidence for the unique kinetics of evoked dopamine release in the patch and matrix compartments of the striatum.Analytical and bioanalytical chemistry · 2021Article
- 3D fuzzy graphene microelectrode array for dopamine sensing at sub-cellular spatial resolution.Biosensors & bioelectronics · 2021Article
- Real-Time Fast Scan Cyclic Voltammetry Detection and Quantification of Exogenously Administered Melatonin in Mice Brain.Frontiers in bioengineering and biotechnology · 2020Article
- Direct in Vivo Electrochemical Detection of Resting Dopamine Using Poly(3,4-ethylenedioxythiophene)/Carbon Nanotube Functionalized Microelectrodes.Analytical chemistry · 2019Article
- Ex Vivo Measurement of Electrically Evoked Dopamine Release in Zebrafish Whole Brain.ACS chemical neuroscience · 2017Article
- Modeling Fast-scan Cyclic Voltammetry Data from Electrically Stimulated Dopamine Neurotransmission Data Using QNsim1.0.Journal of visualized experiments : JoVE · 2017Article
- Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes.Biosensors & bioelectronics · 2017Article
- Subcellular probes for neurochemical recording from multiple brain sites.Lab on a chip · 2017Article
- Computational Modeling of Neurotransmitter Release Evoked by Electrical Stimulation: Nonlinear Approaches to Predicting Stimulation-Evoked Dopamine Release.ACS chemical neuroscience · 2017Article
- Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum.Neuropharmacology · 2016Article
- A review of the effects of FSCV and microdialysis measurements on dopamine release in the surrounding tissue.The Analyst · 2015Review
- Kinetic diversity of dopamine transmission in the dorsal striatum.Journal of neurochemistry · 2015Article
- Microdialysis in the rat striatum: effects of 24 h dexamethasone retrodialysis on evoked dopamine release and penetration injury.ACS chemical neuroscience · 2015Article
- A novel restricted diffusion model of evoked dopamine.ACS chemical neuroscience · 2014Review
- Region- and domain-dependent action of nomifensine.The European journal of neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The rat dorsal striatum exhibits domain-dependent kinetics of dopamine release and clearance. The present report describes the domain-dependent actions of nomifensine (20 mg/kg i.p.), a competitive dopamine uptake inhibitor, on evoked dopamine responses recorded by voltammetry during electrical stimulation of the medial forebrain bundle. In slow domains, nomifensine increases the initial rate of evoked overflow, increases response overshoot, does not affect the slope of the linear segment of the dopamine clearance profile, and slows the non-linear segment of the clearance profile. In fast domains, nomifensine does not affect the initial rate of overflow, increases the end-of-stimulus overshoot, and decreases the slope of the linear segment of the dopamine clearance profile. Collectively, these findings do not concur with existing models of evoked dopamine release that describe the effect of nomifensine as an increase in the effective KM of dopamine uptake. These findings suggest that dopamine clearance after evoked release is affected by both dopamine uptake and a restricted extracellular diffusion process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.