ArticleAllergy, asthma & immunology research2012
Asthma Prevention by Lactobacillus Rhamnosus in a Mouse Model is Associated With CD4(+)CD25(+)Foxp3(+) T Cells.
Article in Allergy, asthma & immunology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 111 citations in OpenAlex.
- Adjunctive Probiotics Alleviates Asthmatic Symptoms via Modulating the Gut Microbiome and Serum Metabolome.Microbiology spectrum · 2021Trial
- Gut microbiota: a novel strategy affecting atherosclerosis.Microbiology spectrum · 2025Review
- Intestinal Lactobacillus johnsonii protects against neuroangiostrongyliasis in BALB/c mice through modulation of immune response.PLoS neglected tropical diseases · 2025Article
- Therapeutic Potential of Arginine-Loaded Red Blood Cell Nanovesicles Targeting Obese Asthma.Mediators of inflammation · 2025Article
- The anti-allergic effect ofFrontiers in nutrition · 2025Article
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- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- The role of DC subgroups in the pathogenesis of asthma.Frontiers in immunology · 2024Review
- Lactobacillus rhamnosus Restores Antiviral Signaling and Attenuates Cytokines Secretion from Human Bronchial Epithelial Cells Exposed to Cigarette Smoke and Infected with SARS-CoV-2.Probiotics and antimicrobial proteins · 2023Article
- Interaction between tissue-dwelling helminth and the gut microbiota drives mucosal immunoregulation.NPJ biofilms and microbiomes · 2023Article
- Helminths and Bacterial Microbiota: The Interactions of Two of Humans' "Old Friends".International journal of molecular sciences · 2022Review
- Investigational Treatments in Phase I and II Clinical Trials: A Systematic Review in Asthma.Biomedicines · 2022Review
- Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma.Clinical and translational allergy · 2022Article
- The lung, the niche, and the microbe: Exploring the lung microbiome in cancer and immunity.Frontiers in immunology · 2022Review
- Regulatory T Cell Modulation byFrontiers in veterinary science · 2022Article
- Effect of Probiotics on Respiratory Tract Allergic Disease and Gut Microbiota.Frontiers in nutrition · 2022Review
- The immunomodulatory effects of Candida albicans isolated from the normal gastrointestinal microbiome of the elderly on colorectal cancer.Medical oncology (Northwood, London, England) · 2021Article
- L. rhamnosus improves the immune response and tryptophan catabolism in laying hen pullets.Scientific reports · 2021Article
- Gut Helminth Infection-Induced Immunotolerance and Consequences for Human Papillomavirus Persistence.The American journal of tropical medicine and hygiene · 2021Review
- Exposure to Polyhexamethylene Guanidine Exacerbates Bronchial Hyperresponsiveness and Lung Inflammation in a Mouse Model of Ovalbumin-Induced Asthma.Allergy, asthma & immunology research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProbiotic bacteria can induce immune regulation or immune tolerance in allergic diseases. The underlying mechanisms have been recently investigated, but are still unclear. The aim of this study was to evaluate the protective effects of the probiotic Lactobacillus rhamnosus (Lcr35) in a mouse model of asthma and to identify its mechanism of action.
methodsLcr35 was administered daily by the oral route at a dosage of 1×10(9) CFU/mouse in BALB/c mice for 7 days before the first sensitization. Clinical parameters and regulatory T (Treg) cells were examined. The role of CD4(+)CD25(+)Foxp3(+) Treg cells was analyzed using a Treg cell-depleting anti-CD25 monoclonal antibody (mAb).
resultsAirway hyperresponsiveness, total IgE production, pulmonary eosinophilic inflammation, and splenic lymphocyte proliferation were suppressed after Lcr35 treatment. Th1 (IFN-γ) and Th2 (IL-4, IL-5, and IL-13) cytokines in the serum were suppressed, and the percentage of CD4(+)CD25(+)Foxp3(+) Treg cells in the spleen was significantly increased in the Lcr35 treatment group. Anti-CD25 mAb administration abolished the protective effects of Lcr35, indicating that CD4(+) CD25(+)Foxp3(+) Treg cells are essential in mediating the activity of Lcr35.
conclusionsOral administration of Lcr35 attenuated the features of allergic asthma in a mouse model and induced immune regulation by a CD4(+)CD25(+)Foxp3(+) Treg cell-mediated mechanism.
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