ReviewNeural plasticity2012
Molecular determinants of the spacing effect.
Review in Neural plasticity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- The massed-spaced learning effect in non-neural human cells.Nature communications · 2024Article
- Synapse-specific structural plasticity that protects and refines local circuits during LTP and LTD.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Network motifs exhibiting a differential response to spaced and massed inputs.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- A behavioral tagging account of kinase contribution to memory formation after spaced aversive training.iScience · 2023Article
- Specific patterns of neural activity in the hippocampus after massed or distributed spatial training.Scientific reports · 2023Article
- Efficacy of spaced learning in adaptation of optokinetic response.Brain and behavior · 2021Article
- Making a Lecture Stick: the Effect of Spaced Instruction on Knowledge Retention in Medical Education.Medical science educator · 2020Article
- Inducing musical-interval learning by combining task practice with periods of stimulus exposure alone.Attention, perception & psychophysics · 2019Article
- Spaced Training Enhances Contextual Fear MemoryFrontiers in molecular neuroscience · 2019Article
- The Interval Between VNS-Tone Pairings Determines the Extent of Cortical Map Plasticity.Neuroscience · 2018Article
- Short-Term Dosage Regimen for Stimulation-Induced Long-Lasting Desynchronization.Frontiers in physiology · 2018Article
- Making Memories: Why Time Matters.Frontiers in human neuroscience · 2018Review
- Intermittent apnea elicits inactivity-induced phrenic motor facilitation via a retinoic acid- and protein synthesis-dependent pathway.Journal of neurophysiology · 2017Article
- Spacing Repetitions Over Long Timescales: A Review and a Reconsolidation Explanation.Frontiers in psychology · 2017Article
- Interaction of inhibitory and facilitatory effects of conditioning trials on long-term memory formation.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The microRNA cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner.Nature communications · 2016Article
- Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory.Molecular neurobiology · 2016Article
- Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity.Frontiers in computational neuroscience · 2016Article
- Histone deacetylase inhibition facilitates massed pattern-induced synaptic plasticity and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training). This spacing effect was observed in a range of organisms from invertebrates to humans. In the present paper, we discuss the evidence supporting cyclic-AMP response element-binding protein 2 (CREB), a transcription factor, as being an important molecule mediating long-term memory formation after spaced training. We also review the main upstream proteins that regulate CREB in different model organisms. Those include the eukaryotic translation initiation factor (eIF2α), protein phosphatase I (PP1), mitogen-activated protein kinase (MAPK), and the protein tyrosine phosphatase corkscrew. Finally, we discuss PKC activation and protein synthesis and degradation as mechanisms by which neurons decode the spacing intervals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.