ArticleScientific reports2012
Engineering a thermo-stable superoxide dismutase functional at sub-zero to >50°C, which also tolerates autoclaving.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 115 citations in OpenAlex.
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- Seed priming with potassium nitrate alleviates the high temperature stress by modulating growth and antioxidant potential in carrot seeds and seedlings.BMC plant biology · 2024Article
- Leaf litter from Cynanchum auriculatum Royle ex Wight leads to root rot outbreaks by Fusarium solani, hindering continuous cropping.FEMS microbiology ecology · 2024Article
- Direct relationship between dimeric form and activity in the acidic copper-zinc superoxide dismutase from lemon.Acta crystallographica. Section F, Structural biology communications · 2023Article
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- Syntrichia caninervis adapt to mercury stress by altering submicrostructure and physiological properties in the Gurbantünggüt Desert.Scientific reports · 2022Article
- Production of a Novel Superoxide Dismutase byFrontiers in nutrition · 2022Article
- Molecular and Biochemical Analysis of Duplicated Cytosolic CuZn Superoxide Dismutases of Rice andFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Superoxide dismutase (SOD) is a critical enzyme associated with controlling oxygen toxicity arising out of oxidative stress in any living system. A hyper-thermostable SOD isolated from a polyextremophile higher plant Potentilla atrosanguinea Lodd. var. argyrophylla (Wall. ex Lehm.) was engineered by mutation of a single amino acid that enhanced the thermostability of the enzyme to twofold. The engineered enzyme was functional from sub-zero temperature to >50°C, tolerated autoclaving (heating at 121°C, at a pressure of 1.1 kg per square cm for 20 min) and was resistant to proteolysis. The present work is the first example to enhance the thermostability of a hyper-thermostable protein and has potential to application to other proteins for enhancing thermostability.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.