ArticleObstetrics and gynecology international2012
Stem cell interaction with somatic niche may hold the key to fertility restoration in cancer patients.
Article in Obstetrics and gynecology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01966536 (CD133+ Autologue Transplantation to Promote Ovarian Follicles Development in Women With Poor Ovarian Reserve.), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
CD133+ Autologue Transplantation to Promote Ovarian Follicles Development in Women With Poor Ovarian Reserve.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Platelet-Rich Plasma (PRP): Molecular Mechanisms, Actions and Clinical Applications in Human Body.International journal of molecular sciences · 2025Review
- The Clinical Application of Platelet-Rich Plasma in the Female Reproductive System: A Narrative Review.Life (Basel, Switzerland) · 2023Review
- Stem cells survive oncotherapy & can regenerate non-functional gonads: A paradigm shift for oncofertility.The Indian journal of medical research · 2018Review
- Making gametes from alternate sources of stem cells: past, present and future.Reproductive biology and endocrinology : RB&E · 2017Review
- Used protocols for isolation and propagation of ovarian stem cells, different cells with different traits.Journal of ovarian research · 2016Review
- Very small embryonic-like stem cells (VSELs) detected in azoospermic testicular biopsies of adult survivors of childhood cancer.Reproductive biology and endocrinology : RB&E · 2015Article
- Mouse Ovarian Very Small Embryonic-Like Stem Cells Resist Chemotherapy and Retain Ability to Initiate Oocyte-Specific Differentiation.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Differential expression of pluripotent and germ cell markers in ovarian surface epithelium according to age in female mice.Reproductive biology and endocrinology : RB&E · 2014Article
- Dynamics associated with spontaneous differentiation of ovarian stem cells in vitro.Journal of ovarian research · 2014Article
- Ovarian stem cells: absence of evidence is not evidence of absence.Journal of ovarian research · 2013Article
- Stimulation of ovarian stem cells by follicle stimulating hormone and basic fibroblast growth factor during cortical tissue culture.Journal of ovarian research · 2013Article
- Follicle stimulating hormone modulates ovarian stem cells through alternately spliced receptor variant FSH-R3.Journal of ovarian research · 2013Article
- Very small embryonic-like stem cells: implications in reproductive biology.BioMed research international · 2013Review
- Germline cells in ovarian surface epithelium of mammalians: a promising notion.Reproductive biology and endocrinology : RB&E · 2012Review
- Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary.Journal of ovarian research · 2012Article
- Gonadotropin treatment augments postnatal oogenesis and primordial follicle assembly in adult mouse ovaries?Journal of ovarian research · 2012Article
- Morphology of ovaries in laron dwarf mice, with low circulating plasma levels of insulin-like growth factor-1 (IGF-1), and in bovine GH-transgenic mice, with high circulating plasma levels of IGF-1.Journal of ovarian research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spontaneous return of fertility after bone marrow transplantation or heterotopic grafting of cryopreserved ovarian cortical tissue has surprised many, and a possible link with stem cells has been proposed. We have reviewed the available literature on ovarian stem cells in adult mammalian ovaries and presented a model that proposes that the ovary harbors two distinct populations of stem cells, namely, pluripotent, quiescent, very small embryonic-like stem cells (VSELs), and slightly larger "progenitor" ovarian germ stem cells (OGSCs). Besides compromising the somatic niche, oncotherapy destroys OGSCs since, like tumor cells, they are actively dividing; however VSELs persist since they are relatively quiescent. BMT or transplanted ovarian cortical tissue may help rejuvenate the ovarian niche, which possibly supports differentiation of persisting VSELs resulting in neo-oogenesis and follicular development responsible for successful pregnancies. Postnatal oogenesis in mammalian ovary from VSELs may be exploited for fertility restoration in cancer survivors including those who were earlier deprived of gametes and/or gonadal tissue cryopreservation options.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.