ArticleCurrent genomics2011
Prospective of Genomics in Revealing Transmission, Reassortment and Evolution of Wildlife-Borne Avian Influenza A (H5N1) Viruses.
Article in Current genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- The Alarming Situation of Highly Pathogenic Avian Influenza Viruses in 2019-2023.Global medical genetics · 2024Review
- Sample size calculation for phylogenetic case linkage.PLoS computational biology · 2021Article
- Molecular Epidemiology of Infectious Zoonotic and Livestock Diseases.Microbiology spectrum · 2020Review
- A study of the relationship between human infection with avian influenza a (H5N6) and environmental avian influenza viruses in Fujian, China.BMC infectious diseases · 2019Article
- Review
- Genomic Analysis of Viral Outbreaks.Annual review of virology · 2016Review
- Novel Highly Pathogenic Avian H5 Influenza A Viruses in Live Poultry Markets, Wuxi City, China, 2013-2014.Open forum infectious diseases · 2016Article
- Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant.Emerging infectious diseases · 2015Article
- Human infectious diseases in the genomics era: where do we go from here?Genome biology · 2014Article
- Extensive gene remodeling in the viral world: new evidence for nongradual evolution in the mobilome network.Genome biology and evolution · 2014Article
- Major emerging and re-emerging zoonoses in China: a matter of global health and socioeconomic development for 1.3 billion.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2014Review
- Evolutionary dynamics of highly pathogenic avian influenza A/H5N1 HA clades and vaccine implementation in Vietnam.Clinical and experimental vaccine research · 2014Review
- Identification of amino acid changes that may have been critical for the genesis of A(H7N9) influenza viruses.Journal of virology · 2014Article
- Reassortment patterns of avian influenza virus internal segments among different subtypes.BMC evolutionary biology · 2014Article
- Mission of randomness.Virulence · 2013Article
- Wildlife health investigations: needs, challenges and recommendations.BMC veterinary research · 2013Article
- Reassortment of NS segments modifies highly pathogenic avian influenza virus interaction with avian hosts and host cells.Journal of virology · 2013Article
- An overview of the highly pathogenic H5N1 influenza virus.Virologica Sinica · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The outbreak of highly pathogenic avian influenza (HPAI) H5N1 disease has led to significant loss of poultry and wild life and case fatality rates in humans of 60%. Wild birds are natural hosts for all avian influenza virus subtypes and over120 bird species have been reported with evidence of H5N1 infection. Influenza A viruses possess a segmented RNA genome and are characterized by frequently occurring genetic reassortment events, which play a very important role in virus evolution and the spread of novel gene constellations in immunologically naïve human and animal populations. Phylogenetic analysis of whole genome or sub-genomic sequences is a standard means for delineating genetic variation, novel reassortment events, and surveillance to trace the global transmission pathways. In this paper, special emphasis is given to the transmission and circulation of H5N1 among wild life populations, and to the reassortment events that are associated with inter-host transmission of the H5N1 viruses when they infect different hosts, such as birds, pigs and humans. In addition, we review the inter-subtype reassortment of the viral segments encoding inner proteins between the H5N1 viruses and viruses of other subtypes, such as H9N2 and H6N1. Finally, we highlight the usefulness of genomic sequences in molecular epidemiological analysis of HPAI H5N1 and the technical limitations in existing analytical methods that hinder them from playing a greater role in virological research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.