Trial reportSleep2012
A controlled trial of CPAP therapy on metabolic control in individuals with impaired glucose tolerance and sleep apnea.
Trial report in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01385995 (A Controlled Trial of Continuous Positive Airway Pressure), which is not on this map. Cited by 82 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Controlled Trial of Continuous Positive Airway Pressure (CPAP) Therapy on Metabolic Control in Individuals With Impaired Glucose Tolerance and Sleep Apnea
Who cites it
82 citing papers in PubMed, 9 syntheses or guidelines pooled it, 182 citations in OpenAlex.
- Gender Differences in the Context of Obstructive Sleep Apnea and Metabolic Diseases.Frontiers in physiology · 2021Pooled it
- Treatment of Adult Obstructive Sleep Apnea With Positive Airway Pressure: An American Academy of Sleep Medicine Systematic Review, Meta-Analysis, and GRADE Assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Pooled it
- Effect of continuous positive airway pressure on glucose metabolism in adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea.Sleep medicine reviews · 2016Pooled it
- Meta-analyses of the Association of Sleep Apnea with Insulin Resistance, and the Effects of CPAP on HOMA-IR, Adiponectin, and Visceral Adipose Fat.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Pooled it
- Effects of continuous positive airway pressure therapy on glycaemic control, insulin sensitivity and body mass index in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2015Pooled it
- Effect of obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2014Pooled it
- Sleep-disordered breathing and gestational diabetes mellitus: a meta-analysis of 9,795 participants enrolled in epidemiological observational studies.Diabetes care · 2013Pooled it
- Meta-analysis: continuous positive airway pressure improves insulin resistance in patients with sleep apnea without diabetes.Annals of the American Thoracic Society · 2013Pooled it
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- Eight Hours of Nightly Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Improves Glucose Metabolism in Patients with Prediabetes. A Randomized Controlled Trial.American journal of respiratory and critical care medicine · 2015Trial
- The effect of bilevel ventilation or modified continuous positive airway pressure on treatment adherence in adults with obstructive sleep apnea: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- The Role of Incretins in Obstructive Sleep Apnea "GLP1RAs and GLP1RA/GIPRAs in OSA".Journal of diabetes · 2025Article
- Obstructive Sleep Apnea and Type 2 Diabetes: An Update.Journal of clinical medicine · 2025Review
- Sleep and Sugar: Deciphering the 2003-2023 Research Landscape on Sleep Disorders and Diabetes Mellitus via Bibliometric Study.Journal of multidisciplinary healthcare · 2025Article
- Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia.Nature communications · 2024Article
- Potential Therapeutic Targets in Obesity, Sleep Apnea, Diabetes, and Fatty Liver Disease.Journal of clinical medicine · 2024Review
- Upsetting the Balance: How Modifiable Risk Factors Contribute to the Progression of Alzheimer's Disease.Biomolecules · 2024Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
STUDY
objectivesTo address whether treatment of sleep apnea improves glucose tolerance.
designRandomized, double-blind crossover study.
settingSleep clinic referrals. PATIENTS: 50 subjects with moderate to severe sleep apnea (AHI > 15) and impaired glucose tolerance.
interventionsSubjects were randomized to 8 weeks of CPAP or sham CPAP, followed by the alternate therapy after a one-month washout. After each treatment, subjects underwent 2-hour OGTT, polysomnography, actigraphy, and measurements of indices of glucose control. MEASUREMENTS AND
resultsThe primary outcome was normalization of the mean 2-h OGTT; a secondary outcome was improvement in the Insulin Sensitivity Index (ISI (0,120). Subjects were 42% men, mean age of 54 (10), BMI of 39 (8), and AHI of 44 (27). Baseline fasting glucose was 104 (12), and mean 2-h OGTT was 110 (57) mg/dL. Seven subjects normalized their mean 2-h OGTT after CPAP but not after sham CPAP, while 5 subjects normalized after sham CPAP but not after CPAP. Overall, there was no improvement in ISI (0,120) between CPAP and sham CPAP (3.6%; 95% CI: [-2.2%, 9.7%]; P = 0.22). However, in those subjects with baseline AHI ≥ 30 (n = 25), there was a 13.3% (95% CI: [5.2%, 22.1%]; P < 0.001) improvement in ISI (0,120) and a 28.7% (95%CI: [-46.5%, -10.9%], P = 0.002) reduction in the 2-h insulin level after CPAP compared to sham CPAP.
conclusionsThis study did not show that IGT normalizes after CPAP in subjects with moderate sleep apnea and obesity. However, insulin sensitivity improved in those with AHI ≥ 30, suggesting beneficial metabolic effects of CPAP in severe sleep apnea. Clinical trials information: ClinicalTrials.gov Identifier: NCT01385995.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.