Evidence map›Paper›PMID 22547886›Full record

ReviewSleep2012

Daytime sleepiness in obesity: mechanisms beyond obstructive sleep apnea--a review.

Lori A Panossian, Sigrid C Veasey

Open access · bronzeAbstract readReview
In one paragraph

Review in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 174 citations in OpenAlex.

  1. Impact of positive airway pressure for chronic hypercapnic respiratory failure on sleep quality: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Sleep and obesity-known interactions and open questions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Association between isocaloric substitution of macronutrient intake with sleep disorders and psychological health in male adults.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
  12. Observational
  13. Napping and Obesity in Adults - What do we Know?Current diabetes reports · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Lori A PanossianCenter for Sleep and Circadian Neurobiology and Department of Medicine, Sleep Division, University of Pennsylvania, Philadelphia, PA, USA. lori.panossian@uphs.upenn.edu
Sigrid C Veasey
Canadian Sleep & Circadian Network · CAUniversity of Pennsylvania · US

Funding

TRAINING PROGRAM/RESPIRATORY NEUROBIOLOGY AND SLEEPT32HL007713 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 1992 to 2022
$11.9M
Intermittent Hypoxia: Mechanisms of HypersomnolenceR01HL079588 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VEASEY, SIGRID C · 2006 to 2015
$3.1M
Sleep Fatigue &Cognitive Correlates in Pediatric HIVR01HL079555 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI STREISAND, RANDI · 2004 to 2007
$1.8M
Upper Airway Nerve Injury in Apnea: BIP-CHOP-SIRT1 CrosstalkR01HL096037 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VEASEY, SIGRID C · 2010 to 2013
$1.6M
NHLBI NIH HHS HL07713NHLBI NIH HHS HL079555NHLBI NIH HHS HL096037NHLBI NIH HHS R01 HL079555NHLBI NIH HHS R01 HL079588NHLBI NIH HHS R01 HL096037NHLBI NIH HHS T32 HL007713
6 · The paper itself

Abstract

Increasing numbers of overweight children and adults are presenting to sleep medicine clinics for evaluation and treatment of sleepiness. Sleepiness negatively affects quality of life, mental health, productivity, and safety. Thus, it is essential to comprehensively address all potential causes of sleepiness. While many obese individuals presenting with hypersomnolence will be diagnosed with obstructive sleep apnea and their sleepiness will improve with effective therapy for sleep apnea, a significant proportion of patients will continue to have hypersomnolence. Clinical studies demonstrate that obesity without sleep apnea is also associated with a higher prevalence of hypersomnolence and that bariatric surgery can markedly improve hypersomnolence before resolution of obstructive sleep apnea. High fat diet in both humans and animals is associated with hypersomnolence. This review critically examines the relationships between sleepiness, feeding, obesity, and sleep apnea and then discusses the hormonal, metabolic, and inflammatory mechanisms potentially contributing to hypersomnolence in obesity, independent of sleep apnea and other established causes of excessive daytime sleepiness.

Indexed as

AnimalsBariatric SurgeryDisorders of Excessive SomnolenceEatingHumansObesitySleepSleep Apnea, ObstructiveWakefulnesshypersomnolenceneurons/metabolismobesityObstructive sleep apneasleep/physiology

Identifiers

PMID22547886
PMCPMC3321419
OpenAlexW2053199399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.