ArticleSleep2012
Sleep duration and body mass index in twins: a gene-environment interaction.
Article in Sleep, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium.Sleep · 2016Pooled it
- Identification of genetic loci affecting body mass index through interaction with multiple environmental factors using structured linear mixed model.Scientific reports · 2021Trial
- Association of stress-related genetic risk and lifestyle factors with BMI in Korean adults.Nutrition research and practice · 2026Article
- A biobank-scale method for learning modulators of gene-environment interaction underlying human complex traits from multiple environmental exposures.bioRxiv : the preprint server for biology · 2026Article
- Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.Hormone research in paediatrics · 2026Review
- The Sleep Expectation-Reality Gap: Exploring Discrepancies Between Perceived and Ideal Sleep Duration in Primary Care Patients.Healthcare (Basel, Switzerland) · 2025Article
- A matched case-control study on the interaction of anxiety, depression, and circadian CLOCK genes (CLOCK, PER2, RORA) in sleep disorders among mental workers.Frontiers in public health · 2025Article
- Association between sleep duration and serum neurofilament light chain levels among adults in the United States.Heliyon · 2024Article
- Review
- Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community-Based Study.Journal of the American Heart Association · 2023Article
- Associations of sleep duration, daytime napping, and snoring with depression in rural China: a cross-sectional study.BMC public health · 2023Article
- Genetics of circadian rhythms and sleep in human health and disease.Nature reviews. Genetics · 2023Review
- Does sleep duration moderate genetic and environmental contributions to cognitive performance?Sleep · 2022Article
- Disparities in sleep duration among American children: effects of race and ethnicity, income, age, and sex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Obese Patients Experience More Severe CSA than Non-Obese Patients.International journal of environmental research and public health · 2022Article
- Insufficient sleep during infancy is correlated with excessive weight gain in childhood: a longitudinal twin cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Short or Long Sleep Duration and CKD: A Mendelian Randomization Study.Journal of the American Society of Nephrology : JASN · 2020Observational
- Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity.International journal of obesity (2005) · 2020Article
- Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study.International journal of obesity (2005) · 2019Article
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Authors and funding
7 authors.
Funding
Abstract
STUDY
objectivesTo examine whether sleep duration modifies genetic and environmental influences on body mass index (BMI).
designGenotype-environment interaction twin study.
settingUniversity of Washington Twin Registry. PATIENTS OR
participantsA population-based sample of US twins (1,088 pairs, 604 monozygotic, 484 dizygotic; 66% female; mean age = 36.6 yr, standard deviation (SD) = 15.9 yr).
interventionsN/A. MEASUREMENTS AND
resultsParticipants self-reported information on height, weight, and sleep. Mean BMI was calculated as 25.3 kg/m² (SD = 5.4) and mean habitual sleep duration was 7.2 hr/night (SD = 1.2). Data were analyzed using biometric genetic interaction models. Overall the heritability of sleep duration was 34%. Longer sleep duration was associated with decreased BMI (P < 0.05). The heritability of BMI when sleep duration was < 7 hr (h² = 70%) was more than twice as large as the heritability of BMI when sleep duration was ≥ 9 hr (h² = 32%); this interaction was significant (P < 0.05).
conclusionsShorter sleep duration is associated with increased BMI and increased genetic influences on BMI, suggesting that shorter sleep duration increases expression of genetic risks for high body weight. At the same time, longer sleep duration may suppress genetic influences on body weight. Future research aiming to identify specific genotypes for BMI may benefit by considering the moderating role of sleep duration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.