ArticleProceedings of the National Academy of Sciences of the United States of America2012
Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance.Cellular & molecular immunology · 2024Article
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- B cell responses to apoptotic cells in MFG-E8-/- mice.PloS one · 2018Article
- Fcµ Receptor Promotes the Survival and Activation of Marginal Zone B Cells and Protects Mice against Bacterial Sepsis.Frontiers in immunology · 2018Article
- Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Phenotyping of autoreactive B cells with labeled nucleosomes in 56R transgenic mice.Scientific reports · 2017Article
- Identification of autoreactive B cells with labeled nucleosomes.Scientific reports · 2017Article
- B-cell tolerance and autoimmunity.F1000Research · 2017Review
- B Cell-Intrinsic IDO1 Regulates Humoral Immunity to T Cell-Independent Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.International immunology · 2014Article
- Light chain editors of anti-DNA receptors in human B cells.The Journal of experimental medicine · 2014Article
- Antibodies that bind complex glycosaminoglycans accumulate in the Golgi.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Excess CD40L does not rescue anti-DNA B cells from clonal anergy.F1000Research · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with the anti-DNA H-chain transgenic mouse lines 3H9 and 56R, well-characterized models for studying B-cell tolerance to nuclear antigens. Excess CD40L did not induce autoantibody production in 3H9 mice in which anergy maintains self-tolerance, nor did it perturb central tolerance, including deletion and receptor editing, of anti-DNA B cells in 56R mice. In contrast, CD40L/56R mice restored a large number of marginal zone (MZ) B cells reactive to Sm/ribonucleoprotein (RNP) and produced autoantibody, whereas these B cells were deleted by apoptosis in MZ of 56R mice. Thus, excess CD40L efficiently blocked tolerance of Sm/RNP-reactive MZ B cells, leading to production of anti-Sm/RNP antibody implicated in the pathogenesis of lupus. These results suggest that self-reactive B cells such as anti-Sm/RNP B cells, which somehow escape tolerance in the bone marrow and migrate to MZ, are tolerized by apoptotic deletion in MZ and that a break in this tolerance may play a role in the pathogenesis of lupus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.