ArticleMolecular and cellular biology2012
Origins and formation of histone methylation across the human cell cycle.
Article in Molecular and cellular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed.
- Newly synthesized histones: passive or active players in the regulation of epigenetic inheritance?Nucleic acids research · 2026Review
- Hat1 Orchestrates Heterochromatin Inheritance by Regulating Localization of H3K9 Methyltransferases.bioRxiv : the preprint server for biology · 2026Article
- Article
- Histone Modifications in the Cell Cycle ofEpigenomes · 2026Review
- Regulation of the heterochromatin spreading reaction byOpen biology · 2023Review
- Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry.Bioscience reports · 2023Article
- Epigenetic inheritance and boundary maintenance at human centromeres.Current opinion in structural biology · 2023Review
- Asymmetric Histone Inheritance: Establishment, Recognition, and Execution.Annual review of genetics · 2022Review
- Dynamical modeling of the H3K27 epigenetic landscape in mouse embryonic stem cells.PLoS computational biology · 2022Article
- Going beyond Polycomb: EZH2 functions in prostate cancer.Oncogene · 2021Review
- A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis.PLoS biology · 2021Article
- Characterization of histone inheritance patterns in the Drosophila female germline.EMBO reports · 2021Article
- Combinatorial Histone H3 Modifications Are Dynamically Altered in Distinct Cell Cycle Phases.Journal of the American Society for Mass Spectrometry · 2021Article
- Quantitative Kinetic Analyses of Histone Turnover Using Imaging and Flow Cytometry.Bio-protocol · 2020Article
- Polycomb Repressive Complex 2: a Dimmer Switch of Gene Regulation in Calvarial Bone Development.Current osteoporosis reports · 2020Review
- Histone modification dynamics as revealed by multicolor immunofluorescence-based single-cell analysis.Journal of cell science · 2020Article
- Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation.Experimental & molecular medicine · 2020Review
- Chromatin Compaction Leads to a Preference for Peripheral Heterochromatin.Biophysical journal · 2020Article
- Interactions With Histone H3 & Tools to Study Them.Frontiers in cell and developmental biology · 2020Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K27 trimethylation, both of which are linked with epigenetic memory and must be stably transmitted from one cellular generation to the next. This report uses a proteomic strategy to interrogate how and when the cell coordinates the formation of histone posttranslational modifications during division. Paramount among the findings is that H3K9 and H3K27 trimethylation begins during S phase but is completed only during the subsequent G(1) phase via two distinct pathways from the unmodified and preexisting dimethylated states. In short, we have systematically characterized the temporal origins and methylation pathways for histone posttranslational modifications during the cell cycle.
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