ArticleMenopause (New York, N.Y.)2012
Surgical menopause and nonvertebral fracture risk among older US women.
Article in Menopause (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The 2012 hormone therapy position statement of: The North American Menopause Society.Menopause (New York, N.Y.) · 2012Guideline
- Osteoporosis and Fracture Risk in Ovarian Cancer: Beyond the Oncologic Burden.Diagnostics (Basel, Switzerland) · 2025Review
- Review
- Surgical Menopause and Frailty Risk in Community-Dwelling Older Women: Study of Osteoporotic Fractures.Journal of the American Geriatrics Society · 2018Article
- Elevated Bone Turnover Markers after Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Breast and Ovarian Cancer.PloS one · 2017Article
- Menopause, Reproductive Life, Hormone Replacement Therapy, and Bone Phenotype at Age 60-64 Years: A British Birth Cohort.The Journal of clinical endocrinology and metabolism · 2016Article
- Estrogen receptor α (ESR1) IVS1-397T>C polymorphism lowers risk of fracture.International journal of clinical and experimental medicine · 2015Article
- Long-term health consequences of premature or early menopause and considerations for management.Climacteric : the journal of the International Menopause Society · 2015Review
- Bone mineral loss induced by anticancer treatment for gynecological malignancies in premenopausal women.Endocrine connections · 2013Article
- Premature ovarian insufficiency: Pathogenesis and management.Journal of mid-life healthReview
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to determine whether older postmenopausal women with a history of bilateral oophorectomy before natural menopause (surgical menopause) have a higher risk of nonvertebral postmenopausal fracture than women with natural menopause.
methodsWe used 21 years of prospectively collected incident fracture data from the ongoing Study of Osteoporotic Fractures, a cohort study of community-dwelling women without previous bilateral hip fracture who were 65 years or older at enrollment, to determine the risk of hip, wrist, and any nonvertebral fracture. χ(2) and t tests were used to compare the two groups on important characteristics. Multivariable Cox proportional hazards regression models stratified by baseline oral estrogen use status were used to estimate the risk of fracture.
resultsBaseline characteristics differed significantly among the 6,616 women within the Study of Osteoporotic Fractures who underwent either surgical (1,157) or natural (5,459) menopause, including mean age at menopause (44.3 ± 7.4 vs 48.9 ± 4.9 y, P < 0.001) and current use of oral estrogen (30.2% vs 6.5%, P < 0.001). Fracture rates were not significantly increased for surgical versus natural menopause, even among women who had never used oral estrogen (hip fracture: hazard ratio [HR], 0.87; 95% CI, 0.63-1.21; wrist fracture: HR, 1.10; 95% CI, 0.78-1.57; any nonvertebral fracture: HR, 1.11; 95% CI, 0.93-1.32).
conclusionsThese data provide some reassurance that the long-term risk of nonvertebral fracture is not substantially increased for postmenopausal women who experienced premenopausal bilateral oophorectomy, compared with postmenopausal women with intact ovaries, even in the absence of postmenopausal estrogen therapy.
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