ReviewNatural product reports2012
The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites.
Review in Natural product reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Review
- Engineering of 10-Deacetylbaccatin III-10-β-O-Acetyltransferase From Taxus Species for Efficient Acetylating Non-Natural Substrates Into Taxol in Nicotiana benthamiana.Plant biotechnology journal · 2026Article
- Designing an oxidase toolbox for site-directed oxidation of taxanes.Nature communications · 2025Article
- TcJAMYC5 positively regulates paclitaxel biosynthesis in Taxus chinensis var. Mairei.Plant molecular biology · 2025Article
- Post-genomic illumination of paclitaxel biosynthesis.Nature plants · 2024Review
- Plants against cancer: towards green Taxol production through pathway discovery and metabolic engineering.aBIOTECH · 2024Review
- Optimization of the fermentation media, mathematical modeling, and enhancement of paclitaxel production by Alternaria alternata after elicitation with pectin.Scientific reports · 2024Article
- Metabolomics analysis of different diameter classes of Taxus chinensis reveals that the resource allocation is related to carbon and nitrogen metabolism.BMC plant biology · 2024Article
- From functional plasticity of two diterpene synthases (IrTPS2/IrKSL3a) to enzyme evolution.ACS catalysis · 2024Article
- Biomimetic tail-to-head terpene cyclizations using the resorcin[4]arene capsule catalyst.Nature protocols · 2024Review
- Microscopic distribution of taxanes in freeze-fixed stems ofFrontiers in chemistry · 2024Article
- Characterization and protein engineering of glycosyltransferases for the biosynthesis of diverse hepatoprotective cycloartane-type saponins in Astragalus membranaceus.Plant biotechnology journal · 2023Article
- Plant (di)terpenoid evolution: from pigments to hormones and beyond.Natural product reports · 2023Review
- Transcriptome analysis provides insights into light condition effect on paclitaxel biosynthesis in yew saplings.BMC plant biology · 2022Article
- A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis.Nature communications · 2022Article
- Design of stable and self-regulated microbial consortia for chemical synthesis.Nature communications · 2022Article
- Taxanes and taxoids of the genus Taxus - A comprehensive inventory of chemical diversity.Phytochemistry · 2021Review
- The Taxus genome provides insights into paclitaxel biosynthesis.Nature plants · 2021Article
- Natural product sciences: an integrative approach to the innovations of plant natural products.Science China. Life sciences · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The biosynthesis of the anti-cancer drug taxol (paclitaxel) has required the collaborative efforts of several research groups to tackle the synthesis and labeling of putative biosynthetic intermediates, in concert with the identification, cloning and functional expression of the biosynthetic genes responsible for the construction of this complex natural product. Based on a combination of precursor labeling and incorporation experiments, and metabolite isolation from Taxus spp., a picture of the complex matrix of pathway oxygenation reactions following formation of the first committed intermediate, taxa-4(5),11(12)-diene, is beginning to emerge. An overview of the current state of knowledge on the early-stages of taxol biosynthesis is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.