ArticleVirulence2012
Salicylate increases the expression of marA and reduces in vitro biofilm formation in uropathogenic Escherichia coli by decreasing type 1 fimbriae expression.
Article in Virulence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- New Frontiers for Old Medications: Repurposing Approved Drugs Against Gram-Negative Bacterial Infections.Microorganisms · 2025Review
- Article
- Type 1 fimbria and P pili: regulatory mechanisms of the prototypical members of the chaperone-usher fimbrial family.Archives of microbiology · 2024Review
- The Mar, Sox, and Rob Systems.EcoSal Plus · 2023Review
- Control of Escherichia coli Serotype O157:H7 Motility and Biofilm Formation by Salicylate and Decanoate: MarA/SoxS/Rob andApplied and environmental microbiology · 2022Article
- What Flips the Switch? Signals and Stress Regulating Extraintestinal PathogenicMicroorganisms · 2021Review
- The multi-drug efflux system AcrABZ-TolC is essential for infection ofJournal of virology · 2021Article
- Antimicrobial Activity of Non-steroidal Anti-inflammatory Drugs on Biofilm: Current Evidence and Potential for Drug Repurposing.Frontiers in microbiology · 2021Article
- Relationship between Virulence and Resistance among Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2020Review
- Evolution of Antibiotic Resistance in Surrogates ofFrontiers in microbiology · 2020Article
- The Escherichia coli MarA protein regulates the ycgZ-ymgABC operon to inhibit biofilm formation.Molecular microbiology · 2019Article
- Antimicrobial Effects of Antipyretics.Antimicrobial agents and chemotherapy · 2017Review
- Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.Applied and environmental microbiology · 2016Article
- Biofilm formation by enteric pathogens and its role in plant colonization and persistence.Microbial biotechnology · 2014Review
- Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?Clinical microbiology reviews · 2013Review
- MarA, SoxS and Rob ofInternational journal of biotechnology for wellness industries · 2013Article
- What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli.Virulence · 2012Article
- Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Escherichia coli is one of the most frequent bacteria implicated in biofilm formation, which is a dynamic process whose first step consists in bacteria adhesion to surfaces through type 1 fimbriae. Salicylate induces a number of morphological and physiological alterations in bacteria including the activation of the transcriptional regulator MarA. In this report the effects of salicylate on biofilm formation and their relationship with MarA were studied. An inverse relationship was observed between in vitro biofilm formation and salicylate concentration added to the culture medium. Salicylate increases the expression of marA and decreases the expression of fimA and fimB genes in the wild-type strain. In addition, the fimA and fimB expression was decreased in a MarR mutant in which marA was also overexpressed. In conclusion, the expression of type 1 fimbriae in presence of salicylate may be regulated by the level of marA expression through fimB regulator, albeit through neither the ompX nor the tolC genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.