Evidence map›Paper›PMID 22546905›Full record

ArticleVirulence2012

What does it take to stick around? Molecular insights into biofilm formation by uropathogenic Escherichia coli.

Maria Hadjifrangiskou, Scott J Hultgren

Open access · goldAbstract readComment
In one paragraph

Article in Virulence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Biofilm Formation by Pathogenic Bacteria: Applying aPathogens (Basel, Switzerland) · 2022
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Maria HadjifrangiskouDepartment of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, MO, USA.
Scott J Hultgren
University of Missouri–St. Louis · USWashington University in St. Louis · US

Funding

MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
NIDDK NIH HHS R01 DK051406
6 · The paper itself

Abstract

Existence in the biofilm state lends bacteria the opportunity to enjoy, at least for a finite amount of time, the benefits of a multicellular entity. The order of events leading to biofilm formation and disassembly has been the topic of interest for numerous studies, aiming to identify factors and mechanisms that underlie this dynamic developmental process. Of particular import is research leveraged at delineating biofilm formation by medically relevant microorganisms, as prevention or eradication of biofilm from medical devices and from within the host pose a serious challenge in the healthcare setting. Recent research describes how a transcriptional regulator modulates biofilm formation in uropathogenic Escherichia coli (UPEC) by affecting the expression of the type 1 adhesive organelles in response to extracellular signals.

Indexed as

Anti-Bacterial AgentsBiofilmsDNA-Binding ProteinsEscherichia coli ProteinsFimbriae, BacterialSalicylatesUropathogenic Escherichia coliAnti-Bacterial AgentsDNA-Binding ProteinsEscherichia coli ProteinsMarA protein, E coliSalicylates

Identifiers

PMID22546905
PMCPMC3442832
OpenAlexW2043263168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.