Evidence map›Paper›PMID 22546900›Full record

ReviewVirulence2012

The role of inflammasome modulation in virulence.

Christopher R Lupfer, Thirumala-Devi Kanneganti

Open access · goldAbstract readReview
In one paragraph

Review in Virulence, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Different modalities of host cell death and their impact onAmerican journal of physiology. Cell physiology · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Inflammasome control of viral infection.Current opinion in virology · 2015
    Review
  13. Review
  14. Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation.Journal of immunology (Baltimore, Md. : 1950) · 2015
    Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher R LupferDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Thirumala-Devi Kanneganti
Ducks Unlimited · US

Funding

Role of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9M
Inflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2M
NIAID NIH HHS AI1010935NIAID NIH HHS R01 AI101935NIAMS NIH HHS AR056296NIAMS NIH HHS R01 AR056296
6 · The paper itself

Abstract

Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.

Indexed as

Host-Pathogen InteractionsBacteriaBacterial InfectionsHumansInflammasomesModels, BiologicalVirulenceVirus DiseasesVirusesInflammasomes

Identifiers

PMID22546900
PMCPMC3442838
OpenAlexW2050324201

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.