ArticleGenome biology and evolution2012
Elephant transcriptome provides insights into the evolution of eutherian placentation.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Cross-species insights into placental evolution and diseases at the single-cell resolution.Nature communications · 2026Article
- Transcriptomic analysis of primate placentas and novel rhesus trophoblast cell lines informs investigations of human placentation.BMC biology · 2021Article
- Revisiting traditional SSR based methodologies available for elephant genetic studies.Scientific reports · 2021Article
- Evolutionary transcriptomics implicateseLife · 2021Article
- Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy.International journal of molecular sciences · 2019Review
- De novo characterization of placental transcriptome in the Eurasian beaver (Castor fiber L.).Functional & integrative genomics · 2019Article
- Evidence for functional interactions between the placenta and brain in pregnant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Recent advances in understanding evolution of the placenta: insights from transcriptomics.F1000Research · 2018Review
- An endogenous retroviral envelope syncytin and its cognate receptor identified in the viviparous placentalProceedings of the National Academy of Sciences of the United States of America · 2017Article
- The core transcriptome of mammalian placentas and the divergence of expression with placental shape.Placenta · 2017Article
- The evolution of duplicate gene expression in mammalian organs.Genome research · 2017Article
- Reptile Pregnancy Is Underpinned by Complex Changes in Uterine Gene Expression: A Comparative Analysis of the Uterine Transcriptome in Viviparous and Oviparous Lizards.Genome biology and evolution · 2016Article
- Parallel evolution of male germline epigenetic poising and somatic development in animals.Nature genetics · 2016Article
- Poised for development.Nature genetics · 2016Article
- From sauropsids to mammals and back: New approaches to comparative cortical development.The Journal of comparative neurology · 2016Review
- Comparative sequence analyses of genome and transcriptome reveal novel transcripts and variants in the Asian elephant Elephas maximus.Journal of biosciences · 2015Article
- Genetic recapitulation of human pre-eclampsia risk during convergent evolution of reduced placental invasiveness in eutherian mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Evolutionary forward genomics reveals novel insights into the genes and pathways dysregulated in recurrent early pregnancy loss.Human reproduction (Oxford, England) · 2015Article
- Demystifying animal models of adverse pregnancy outcomes: touching bench and bedside.American journal of reproductive immunology (New York, N.Y. : 1989) · 2013Article
- Maternal-fetal unit interactions and eutherian neocortical development and evolution.Frontiers in neuroanatomy · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The chorioallantoic placenta connects mother and fetus in eutherian pregnancies. In order to understand the evolution of the placenta and provide further understanding of placenta biology, we sequenced the transcriptome of a term placenta of an African elephant (Loxodonta africana) and compared these data with RNA sequence and microarray data from other eutherian placentas including human, mouse, and cow. We characterized the composition of 55,910 expressed sequence tag (i.e., cDNA) contigs using our custom annotation pipeline. A Markov algorithm was used to cluster orthologs of human, mouse, cow, and elephant placenta transcripts. We found 2,963 genes are commonly expressed in the placentas of these eutherian mammals. Gene ontology categories previously suggested to be important for placenta function (e.g., estrogen receptor signaling pathway, cell motion and migration, and adherens junctions) were significantly enriched in these eutherian placenta-expressed genes. Genes duplicated in different lineages and also specifically expressed in the placenta contribute to the great diversity observed in mammalian placenta anatomy. We identified 1,365 human lineage-specific, 1,235 mouse lineage-specific, 436 cow lineage-specific, and 904 elephant-specific placenta-expressed (PE) genes. The most enriched clusters of human-specific PE genes are signal/glycoprotein and immunoglobulin, and humans possess a deeply invasive human hemochorial placenta that comes into direct contact with maternal immune cells. Inference of phylogenetically conserved and derived transcripts demonstrates the power of comparative transcriptomics to trace placenta evolution and variation across mammals and identified candidate genes that may be important in the normal function of the human placenta, and their dysfunction may be related to human pregnancy complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.