ArticleGenome medicine2012
Genetic determinants of metabolism in health and disease: from biochemical genetics to genome-wide associations.
Article in Genome medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Decoding rare inherited metabolic disorders: advancing precision in screening and diagnosis.Orphanet journal of rare diseases · 2026Review
- Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.Molecular psychiatry · 2025Article
- Harnessing NMR technology for enhancing field crop improvement: applications, challenges, and future perspectives.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Modeling blood metabolite homeostatic levels reduces sample heterogeneity across cohorts.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Assessing the Biological Mechanisms Linking Smoking Behavior and Cognitive Function: A Mediation Analysis of Untargeted Metabolomics.Metabolites · 2023Article
- Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility.American journal of human genetics · 2022Article
- Urinary metabolic phenotyping for Alzheimer's disease.Scientific reports · 2020Article
- Implication of gut microbiota metabolites in cardiovascular and metabolic diseases.Cellular and molecular life sciences : CMLS · 2018Review
- Nutritional metabolomics in critical illness.Current opinion in clinical nutrition and metabolic care · 2018Review
- Propelling the paradigm shift from reductionism to systems nutrition.Genes & nutrition · 2017Article
- A Systematic Evaluation of Blood Serum and Plasma Pre-Analytics for Metabolomics Cohort Studies.International journal of molecular sciences · 2016Article
- Methylation potential associated with diet, genotype, protein, and metabolite levels in the Delta Obesity Vitamin Study.Genes & nutrition · 2014Article
- Big data: the next frontier for innovation in therapeutics and healthcare.Expert review of clinical pharmacology · 2014Review
- Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links.PLoS genetics · 2014Article
- Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research.Current nutrition reports · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasingly sophisticated measurement technologies have allowed the fields of metabolomics and genomics to identify, in parallel, risk factors of disease; predict drug metabolism; and study metabolic and genetic diversity in large human populations. Yet the complementarity of these fields and the utility of studying genes and metabolites together is belied by the frequent separate, parallel applications of genomic and metabolomic analysis. Early attempts at identifying co-variation and interaction between genetic variants and downstream metabolic changes, including metabolic profiling of human Mendelian diseases and quantitative trait locus mapping of individual metabolite concentrations, have recently been extended by new experimental designs that search for a large number of gene-metabolite associations. These approaches, including metabolomic quantitiative trait locus mapping and metabolomic genome-wide association studies, involve the concurrent collection of both genomic and metabolomic data and a subsequent search for statistical associations between genetic polymorphisms and metabolite concentrations across a broad range of genes and metabolites. These new data-fusion techniques will have important consequences in functional genomics, microbial metagenomics and disease modeling, the early results and implications of which are reviewed.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.