ArticleBreast cancer research : BCR2012
PTHrP and breast cancer: more than hypercalcemia and bone metastases.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Relapsed Chronic Lymphocytic Leukemia Heralded by Parathyroid Hormone Related Peptide-Mediated Hypercalcemia.Clinical case reports · 2025Article
- MiR-556-5p modulates migration, invasion, and epithelial-mesenchymal transition in breast cancer cells via targeting PTHrP.Journal of molecular histology · 2022Article
- Metastatic Breast Cancer Masked as Constipation.Cureus · 2021Article
- Sorting Nexin 27 as a potential target in G protein‑coupled receptor recycling for cancer therapy (Review).Oncology reports · 2020Review
- Association of calcium sensing receptor polymorphisms at rs1801725 with circulating calcium in breast cancer patients.BMC cancer · 2017Article
- An unusual mediastinal parathyroid carcinoma coproducing PTH and PTHrP: A case report.Oncology letters · 2016Article
- MicroRNAs in the control of metastatic bone disease.Trends in endocrinology and metabolism: TEM · 2014Review
- Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells.BMC musculoskeletal disorders · 2013Article
- The osteoblastic and osteoclastic interactions in spinal metastases secondary to prostate cancer.Cancer growth and metastasis · 2013Review
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2 authors at 1 institution in 1 country.
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Abstract
Parathyroid hormone-related protein (PTHrP) causes hypercalcemia in cancer patients. PTHrP is required for normal breast development and has been shown to promote bone metastases from breast cancers. However, whether the protein also contributes to the formation of primary tumors has been unclear. Two recent papers suggest it may. First, a report in Nature Genetics identified the PTHrP locus as a new breast cancer susceptibility gene. Second, a paper in Journal of Clinical Investigation demonstrated that PTHrP promotes tumor growth and metastases in MMTV-PyMT mice. These studies implicate PTHrP in the development and growth of primary breast tumors and underscore the need for further research.
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