ArticleVeterinary research2012
Involvement of the skin during bluetongue virus infection and replication in the ruminant host.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Re-parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.Transboundary and emerging diseases · 2022Pooled it
- Immune responses of Bos indicus versus Bos taurus cattle towards Bluetongue virus or Schmallenberg virus differ significantly.Communications biology · 2026Article
- Bluetongue's New Frontier-Are Dogs at Risk?Veterinary sciences · 2025Review
- Engineering recombinant replication-competent bluetongue viruses expressing reporter genes forMicrobiology spectrum · 2024Article
- Specific T-cell subsets have a role in anti-viral immunity and pathogenesis but not viral dynamics or onwards vector transmission of an important livestock arbovirus.Frontiers in immunology · 2024Article
- Article
- Comprehensive immune profiling reveals thatFrontiers in immunology · 2023Article
- Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences.Animals : an open access journal from MDPI · 2021Review
- Putative Novel Atypical BTV Serotype '36' Identified in Small Ruminants in Switzerland.Viruses · 2021Article
- Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral Infections.International journal of molecular sciences · 2020Article
- Attenuation of Bluetongue Virus (BTV) in anViruses · 2019Article
- Review
- Physiological and immunological responses to Culicoides sonorensis blood-feeding: a murine model.Parasites & vectors · 2018Article
- Bluetongue: control, surveillance and safe movement of animals.EFSA journal. European Food Safety Authority · 2017Article
- Article
- Follicular dendritic cell disruption as a novel mechanism of virus-induced immunosuppression.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts.Scientific reports · 2016Article
- Pathological Characterization Of IFNAR(-/-) Mice Infected With Bluetongue Virus Serotype 4.International journal of biological sciences · 2016Article
- A review of experimental infections with bluetongue virus in the mammalian host.Virus research · 2014Review
- Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Bluetongue virus (BTV) is a double stranded (ds) RNA virus (genus Orbivirus; family Reoviridae), which is considered capable of infecting all species of domestic and wild ruminants, although clinical signs are seen mostly in sheep. BTV is arthropod-borne ("arbovirus") and able to productively infect and replicate in many different cell types of both insects and mammalian hosts. Although the organ and cellular tropism of BTV in ruminants has been the subject of several studies, many aspects of its pathogenesis are still poorly understood, partly because of inherent problems in distinguishing between "virus replication" and "virus presence".BTV replication and organ tropism were studied in a wide range of infected sheep tissues, by immuno-fluorescence-labeling of non-structural or structural proteins (NS2 or VP7 and core proteins, respectively) using confocal microscopy to distinguish between virus presence and replication. These results are compared to gross and microscopic pathological findings in selected organs from infected sheep. Replication was demonstrated in two major cell types: vascular endothelial cells, and agranular leukocytes which morphologically resemble lymphocytes, monocytes/macrophages and/or dendritic cells. Two organs (the skin and tonsils) were shown to support relatively high levels of BTV replication, although they have not previously been proposed as important replication sites during BTV infection. The high level of BTV replication in the skin is thought to be of major significance for the pathogenesis and transmission of BTV (via biting insects) and a refinement of our current model of BTV pathogenesis is discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.