ArticleBMC microbiology2012
Multilocus genetics to reconstruct aeromonad evolution.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
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- Analysis of global Aeromonas veronii genomes provides novel information on source of infection and virulence in human gastrointestinal diseases.BMC genomics · 2022Article
- Recent Insights intoJournal of microbiology and biotechnology · 2020Review
- Genetic relatedness and novel sequence types of clinical Aeromonas dhakensis from Malaysia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Comparative and Evolutionary Genomics of Isolates Provide Insight into the Pathoadaptation of Aeromonas.Genome biology and evolution · 2020Article
- An Update on the GenusMicroorganisms · 2020Review
- Aeromonas caviae mimicking Vibrio cholerae infectious enteropathy in a cholera-endemic region with possible public health consequences: two case reports.Journal of medical case reports · 2018Article
- Article
- Genotypic and Lipid Analyses of Strains From the Archaeal GenusFrontiers in microbiology · 2018Article
- Species Delimitation, Phylogenetic Relationships, and Temporal Divergence Model in the GenusFrontiers in microbiology · 2018Article
- Genome-driven evaluation and redesign of PCR tools for improving the detection of virulence-associated genes in aeromonads.PloS one · 2018Article
- Delineation of Taxonomic Species within Complex of Species:Frontiers in microbiology · 2017Article
- DistinctFrontiers in microbiology · 2017Article
- Taxonomy and systematics of plant probiotic bacteria in the genomic era.AIMS microbiology · 2017Review
- Evolutionary Roots and Diversification of the GenusFrontiers in microbiology · 2017Article
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Authors and funding
6 authors.
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Abstract
backgroundAeromonas spp. are versatile bacteria that exhibit a wide variety of lifestyles. In an attempt to improve the understanding of human aeromonosis, we investigated whether clinical isolates displayed specific characteristics in terms of genetic diversity, population structure and mode of evolution among Aeromonas spp. A collection of 195 Aeromonas isolates from human, animal and environmental sources was therefore genotyped using multilocus sequence analysis (MLSA) based on the dnaK, gltA, gyrB, radA, rpoB, tsf and zipA genes.
resultsThe MLSA showed a high level of genetic diversity among the population, and multilocus-based phylogenetic analysis (MLPA) revealed 3 major clades: the A. veronii, A. hydrophila and A. caviae clades, among the eleven clades detected. Lower genetic diversity was observed within the A. caviae clade as well as among clinical isolates compared to environmental isolates. Clonal complexes, each of which included a limited number of strains, mainly corresponded to host-associated subsclusters of strains, i.e., a fish-associated subset within A. salmonicida and 11 human-associated subsets, 9 of which included only disease-associated strains. The population structure was shown to be clonal, with modes of evolution that involved mutations in general and recombination events locally. Recombination was detected in 5 genes in the MLSA scheme and concerned approximately 50% of the STs. Therefore, these recombination events could explain the observed phylogenetic incongruities and low robustness. However, the MLPA globally confirmed the current systematics of the genus Aeromonas.
conclusionsEvolution in the genus Aeromonas has resulted in exceptionally high genetic diversity. Emerging from this diversity, subsets of strains appeared to be host adapted and/or "disease specialized" while the A. caviae clade displayed an atypical tempo of evolution among aeromonads. Considering that A. salmonicida has been described as a genetically uniform pathogen that has adapted to fish through evolution from a variable ancestral population, we hypothesize that the population structure of aeromonads described herein suggested an ongoing process of adaptation to specialized niches associated with different degrees of advancement according to clades and clusters.
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