ReviewMicrobial cell factories2012
Recent advances in engineering the central carbon metabolism of industrially important bacteria.
Review in Microbial cell factories, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 135 citations in OpenAlex.
- Comparative analysis of physicochemical properties, functional activities, and metabolomics ofFood chemistry: X · 2026Article
- Cellulose saccharification to alleviate CCR of xylose for enhanced 1, 2, 4-butanetriol production.Biodesign research · 2026Article
- Effects of heterologous expression of glycolysis enzymes on product formation inMetabolic engineering communications · 2026Article
- Meta-analysis of fruit waste-derived single-cell protein for programmable nutrition via synthetic biology in sustainable food systems.NPJ science of food · 2026Article
- A GTP-driven central carbon metabolism in the cellulolytic bacterium Ruminiclostridium cellulolyticum.Communications biology · 2025Article
- Transcriptomic analysis reveals differential gene expression patterns of Lacticaseibacillus casei ATCC 393 in response to ultrasound stress.Ultrasonics sonochemistry · 2024Article
- Peanut-based intercropping systems altered soil bacterial communities, potential functions, and crop yield.PeerJ · 2024Article
- Genomics-Guided Efficient Identification of 2,5-Diketopiperazine Derivatives from Actinobacteria.Chembiochem : a European journal of chemical biology · 2023Article
- Integrated genomics and proteomics analysis of Paenibacillus peoriae IBSD35 and insights into its antimicrobial characteristics.Scientific reports · 2022Article
- Article
- Flux-Balance Analysis and Mobile CRISPRi-Guided Deletion of a Conditionally Essential Gene inACS synthetic biology · 2022Article
- Whole-genome sequencing and analysis of Streptomyces strains producing multiple antinematode drugs.BMC genomics · 2022Article
- Biotechnological production of specialty aromatic and aromatic-derivative compounds.World journal of microbiology & biotechnology · 2022Review
- Medium optimization for high mycelial soluble protein content ofFrontiers in microbiology · 2022Article
- Review
- Review
- An Actinobacterial Isolate,Microorganisms · 2021Article
- Biotechnological Production of the Sunscreen Pigment Scytonemin in Cyanobacteria: Progress and Strategy.Marine drugs · 2021Review
- Editorial: Technological Advances Improving Recombinant Protein Production in Bacteria.Frontiers in microbiology · 2021Article
- Antibacterial Activity and Multi-Targeting Mechanism of Dehydrocorydaline FromFrontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper gives an overview of the recent advances in engineering the central carbon metabolism of the industrially important bacteria Escherichia coli, Bacillus subtilis, Corynobacterium glutamicum, Streptomyces spp., Lactococcus lactis and other lactic acid bacteria. All of them are established producers of important classes of products, e.g. proteins, amino acids, organic acids, antibiotics, high-value metabolites for the food industry and also, promising producers of a large number of industrially or therapeutically important chemicals. Optimization of existing or introduction of new cellular processes in these microorganisms is often achieved through manipulation of targets that reside at major points of central metabolic pathways, such as glycolysis, gluconeogenesis, the pentose phosphate pathway and the tricarboxylic acid cycle with the glyoxylate shunt. Based on the huge progress made in recent years in biochemical, genetic and regulatory studies, new fascinating engineering approaches aim at ensuring an optimal carbon and energy flow within central metabolism in order to achieve optimized metabolite production.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.