ArticleBMC gastroenterology2012
Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat.
Article in BMC gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.Journal of cancer research and clinical oncology · 2025Trial
- Atomoxetine attenuates methotrexate-induced lung injury in rats implicating TLR4/NF-κB and Bax/Bcl-2/caspase-3 signaling cascades: a study based on molecular docking and experimental validation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Folic acid deficiency in cancer therapy: a review of chemotherapy-induced malabsorption and supportive care strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Non-targeted Metabolomic and Intestinal Microbiota Analysis of Ligilactobacillus salivarius X9 in Enterotoxigenic Escherichia coli K88-induced Enteritis in Mice.Probiotics and antimicrobial proteins · 2026Article
- Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK/NF-κB Signaling Pathway.Biochemical genetics · 2024Article
- Nitazoxanide mitigates methotrexate hepatotoxicity in rats: role in inhibiting apoptosis and regulating endoplasmic reticulum stress.Frontiers in pharmacology · 2024Article
- Potential Hepatoprotective Effects ofAntioxidants (Basel, Switzerland) · 2023Article
- Evaluation of the Protective Effect of Citral, Silymarin, and Thymoquinone on Methotrexate-Induced Lung Injury in Rats.Journal of pharmacopuncture · 2023Article
- Water- and feed-based arginine impacts on gut integrity in weanling pigs.Translational animal science · 2023Article
- Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis-The Role of Drug Efflux Transporters.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Effects of dietary components on intestinal permeability in health and disease.American journal of physiology. Gastrointestinal and liver physiology · 2020Review
- Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b.Communications biology · 2020Article
- Ghrelin, a novel therapy, corrects cytokine and NF-κB-AKT-MAPK network and mitigates intestinal injury induced by combined radiation and skin-wound trauma.Cell & bioscience · 2020Article
- L-Arginine alleviates heat stress-induced intestinal epithelial barrier damage by promoting expression of tight junction proteins via the AMPK pathway.Molecular biology reports · 2019Article
- Arginine affects growth and integrity of grass carp enterocytes by regulating TOR signaling pathway and tight junction proteins.Fish physiology and biochemistry · 2019Article
- Induction and Amelioration of Methotrexate-Induced Gastrointestinal Toxicity are Related to Immune Response and Gut Microbiota.EBioMedicine · 2018Article
- Regulation of Intestinal Epithelial Cells Properties and Functions by Amino Acids.BioMed research international · 2018Review
- Protective Mechanisms of Thymoquinone on Methotrexate-induced Intestinal Toxicity in Rats.Pharmacognosy magazine · 2016Article
- The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes.Cell metabolism · 2015Review
- Protective effects of carvacrol and pomegranate against methotrexate-induced intestinal damage in rats.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArginine (ARG) and nitric oxide maintain the mucosal integrity of the intestine in various intestinal disorders. In the present study, we evaluated the effects of oral ARG supplementation on intestinal structural changes, enterocyte proliferation and apoptosis following methotrexate (MTX)-induced intestinal damage in a rat.
methodsMale rats were divided into four experimental groups: Control rats, CONTR-ARG rats, were treated with oral ARG given in drinking water 72 hours before and 72 hours following vehicle injection, MTX rats were treated with a single dose of methotrexate, and MTX-ARG rats were treated with oral ARG following injection of MTX. Intestinal mucosal damage, mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined 72 hours following MTX injection. RT-PCR was used to determine bax and bcl-2 mRNA expression.
resultsMTX-ARG rats demonstrated greater jejunal and ileal bowel weight, greater ileal mucosal weight, greater ileal mucosal DNA and protein levels, greater villus height in jejunum and ileum and crypt depth in ileum, compared to MTX animals. A significant decrease in enterocyte apoptosis in the ileum of MTX-ARG rats (vs MTX) was accompanied by decreased bax mRNA and protein expression and increased bcl-2 protein levels.
conclusionsTreatment with oral ARG prevents mucosal injury and improves intestinal recovery following MTX- injury in the rat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.