ArticleSmall GTPases2011
Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway.
Article in Small GTPases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Electrical stimulation promotes structural plasticity in cortical spheroids by modulating N-cadherin-dependent collective migration and mechanotransduction.Biomedical engineering letters · 2026Article
- Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption.Neurobiology of disease · 2025Article
- Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.International journal of molecular sciences · 2021Article
- Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development.Molecular and cellular biology · 2020Article
- Reelin Functions, Mechanisms of Action and Signaling Pathways During Brain Development and Maturation.Biomolecules · 2020Review
- How Do Cortical Excitatory Neurons Terminate Their Migration at the Right Place? Critical Roles of Environmental Elements.Frontiers in cell and developmental biology · 2020Review
- Article
- The Mechanism of Rap1 Regulates N-cadherin to Control Neuronal Migration.Journal of molecular neuroscience : MN · 2019Article
- The Ras Superfamily of Small GTPases in Non-neoplastic Cerebral Diseases.Frontiers in molecular neuroscience · 2019Review
- Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis.Scientific reports · 2017Article
- Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex.Frontiers in cellular neuroscience · 2017Review
- Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks.Frontiers in cellular neuroscience · 2017Review
- Canonical and Non-canonical Reelin Signaling.Frontiers in cellular neuroscience · 2016Review
- Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Polarity transitions during neurogenesis and germinal zone exit in the developing central nervous system.Frontiers in cellular neuroscience · 2015Review
- Cadherins as regulators of neuronal polarity.Cell adhesion & migration · 2015Review
- Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle.The Journal of biological chemistry · 2014Article
- Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway.The Journal of biological chemistry · 2014Article
- The dynamic of the apical ectoplasmic specialization between spermatids and Sertoli cells: the case of the small GTPase Rap1.BioMed research international · 2014Review
- The involvement of Reelin in neurodevelopmental disorders.Neuropharmacology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal migration is essential for the development of the cerebral cortex. Mutations leading to defective migration are associated with numerous brain pathologies. An important challenge in the field is to understand the intrinsic and extrinsic mechanisms that regulate neuronal migration during normal development and in disease. Many small GTPases are expressed in the central nervous system during embryonic development. Recent findings have shown that Rap1 and its downstream partners Ral, Rac and Cdc42 are involved in the maintenance of N-Cadherin at the plasma membrane which is necessary for the correct polarization of migrating neurons. The activation of Rap1 is triggered by Reelin, an extracellular protein known for its role in the organization of the cortex into layers of neurons. In the absence of Reelin, neurons exhibit a broader and irregular pattern of positioning. The prevailing model suggests that Reelin signals to neurons during the last step of their migration, a notion that is inconsistent with new data describing an effect of Reelin on early steps of migration. In regard to these recent findings I suggest a revised model, which I call the "polarity model," that further refines our understanding of the developmental function played by Reelin and its downstream small GTPases.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.