Evidence map›Paper›PMID 22545215›Full record

ArticleJournal of neuroparasitology2012

The Impact of HIV Coinfection on Cerebral Malaria Pathogenesis.

Sarah Hochman, Kami Kim

Open access · diamondAbstract read
In one paragraph

Article in Journal of neuroparasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Global HIV neurology: a comprehensive review.AIDS (London, England) · 2019
    Review
  4. Article
  5. Parasite epidemiology and control · 2018
    Article
  6. Article
  7. Global Epidemiology of Plasmodium vivax.The American journal of tropical medicine and hygiene · 2016
    Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sarah HochmanAlbert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
Kami Kim
Albert Einstein College of Medicine · US

Funding

Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI PORCELLI, STEVEN A · 2003 to 2013
$18.6M
A Systems Biology Approach to the Model Apicomplexan Toxoplasma gondiiRC4AI092801 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KIM, KAMI, SULLIVAN, WILLIAM J · 2010 to 2010
$5.6M
Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Toxoplasma Epigenomics and Gene ExpressionR01AI087625 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KIM, KAMI · 2010 to 2014
$3.5M
SERINE PROTEINASES IN APICOMPLEXAN PARASITESR01AI046985 · NIAID · YESHIVA UNIVERSITY · PI KIM, KAMI · 2000 to 2009
$2.7M
HIV/Malaria Coinfection Effects on Immune Dysfunction and the Blood-Brain BarrierK08MH089848 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HOCHMAN, SARAH E · 2010 to 2014
$746k
NIAID NIH HHS L40 AI084461NIAID NIH HHS P30 AI051519NIAID NIH HHS R01 AI046985NIAID NIH HHS R01 AI087625NIAID NIH HHS RC4 AI092801NIAID NIH HHS T32 AI070117NIMH NIH HHS K08 MH089848
6 · The paper itself

Abstract

HIV infection is widespread throughout the world and is especially prevalent in sub-Saharan Africa and Asia. Similarly, Plasmodium falciparum, the most common cause of severe malaria, affects large areas of sub-Saharan Africa, the Indian subcontinent, and Southeast Asia. Although initial studies suggested that HIV and malaria had independent impact upon patient outcomes, recent studies have indicated a more significant interaction. Clinical studies have shown that people infected with HIV have more frequent and severe episodes of malaria, and parameters of HIV disease progression worsen in individuals during acute malaria episodes. However, the effect of HIV on development of cerebral malaria, a manifestation of P. falciparum infection that is frequently fatal, has not been characterized. We review clinical and basic science studies pertaining to HIV and malaria coinfection and cerebral malaria in particular in order to highlight the likely role HIV plays in exacerbating cerebral malaria pathogenesis.

Identifiers

PMID22545215
PMCPMC3336366
OpenAlexW2119119662

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.