ArticleJournal of parasitology research2012
Toxoplasma on the brain: understanding host-pathogen interactions in chronic CNS infection.
Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Pooled it
- Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk.Progress in neuro-psychopharmacology & biological psychiatry · 2019Pooled it
- The Association between Toxoplasma gondii Infection and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis.BioMed research international · 2019Pooled it
- Seroepidemiology of Toxoplasma gondii infection in people with alcohol consumption in Durango, Mexico.PloS one · 2021Trial
- Effects of latent infection of Toxoplasma gondii strains with different genotypes on mouse behavior and brain transcripts.Parasites & vectors · 2025Article
- Adverse pregnancy outcomes in Toxoplasma gondii seropositive Hispanic women.The journal of obstetrics and gynaecology research · 2023Article
- Article
- Inhibition ofFrontiers in cellular and infection microbiology · 2022Article
- Host sensing and signal transduction during Toxoplasma stage conversion.Molecular microbiology · 2021Review
- Galectins - Important players of the immune response to CNS parasitic infection.Brain, behavior, & immunity - health · 2021Review
- Neurological and Neurobehavioral Disorders Associated withJournal of parasitology research · 2021Review
- Food Safety Considerations Related to the Consumption and Handling of Game Meat in North America.Veterinary sciences · 2020Review
- Article
- Article
- The Impact of the Antigenic Composition of Chimeric Proteins on Their Immunoprotective Activity against Chronic Toxoplasmosis in Mice.Vaccines · 2019Article
- The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.PLoS pathogens · 2019Article
- Review
- Novel Toxoplasma gondii inhibitor chemotypes.Parasitology international · 2018Article
- In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging.Virulence · 2018Review
- Characteristics of Infection Immunity Regulated byFrontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Toxoplasma gondii is a prevalent obligate intracellular parasite which chronically infects more than a third of the world's population. Key to parasite prevalence is its ability to form chronic and nonimmunogenic bradyzoite cysts, which typically form in the brain and muscle cells of infected mammals, including humans. While acute clinical infection typically involves neurological and/or ocular damage, chronic infection has been more recently linked to behavioral changes. Establishment and maintenance of chronic infection involves a balance between the host immunity and parasite evasion of the immune response. Here, we outline the known cellular interplay between Toxoplasma gondii and cells of the central nervous system and review the reported effects of Toxoplasma gondii on behavior and neurological disease. Finally, we review new technologies which will allow us to more fully understand host-pathogen interactions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.