ReviewCurrent osteoporosis reports2012
Role of insulin-like growth factor-1 in the regulation of skeletal growth.
Review in Current osteoporosis reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Skeletal consequences of preterm birth in pigs as a model for preterm infants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Association of type 2 Diabetes Mellitus and bone mineral density: a two-sample Mendelian randomization study.BMC musculoskeletal disorders · 2024Article
- Association between serum insulin-like growth factor-1 and bone mineral density in patients with type 2 diabetes.Frontiers in endocrinology · 2024Article
- Convergent genomic signatures of local adaptation across a continental-scale environmental gradient.Science advances · 2023Article
- Altered IGF-I activity and accelerated bone elongation in growth plates precede excess weight gain in a mouse model of juvenile obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Intra-iliac bone marrow injection as a novel alternative to intra-tibial inoculation in rat model.Stem cell research & therapy · 2021Article
- Article
- Biological Factors, Metals, and Biomaterials Regulating Osteogenesis through Autophagy.International journal of molecular sciences · 2020Review
- Estrogen Stimulation of Pleiotrophin Enhances Osteoblast Differentiation and Maintains Bone Mass in IGFBP-2 Null Mice.Endocrinology · 2020Article
- Predicting the vulnerability of birds to trophic threat posed by phenological mismatch based on nutritional and physiological status of nestlings.Conservation physiology · 2019Article
- Deubiquitinating Enzymes and Bone Remodeling.Stem cells international · 2018Review
- Gene-Expression Analysis Identifies IGFBP2 Dysregulation in Dental Pulp Cells From Human Cleidocranial Dysplasia.Frontiers in genetics · 2018Article
- The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification.Bone research · 2018Article
- Imaging IGF-I uptake in growth plate cartilage using in vivo multiphoton microscopy.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Effects of exogenous growth hormone administration on dexamethasone-induced growth impairment in adolescent male rats.Experimental and therapeutic medicine · 2017Article
- Receptor-mediated selective impairment of insulin-like growth factor-1 activity in congenital disorders of glycosylation patients.Pediatric research · 2017Article
- Stress and Alterations in Bones: An Interdisciplinary Perspective.Frontiers in endocrinology · 2017Review
- Skeletal effects of growth hormone and insulin-like growth factor-I therapy.Molecular and cellular endocrinology · 2016Review
- IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation.Endocrinology · 2016Article
- Lactoferrin promote primary rat osteoblast proliferation and differentiation via up-regulation of insulin-like growth factor-1 expression.Molecular biology reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and bone mineral density, two important determinants of bone strength, has been well established from clinical studies involving patients with growth hormone deficiency and IGF-I gene disruption. Data from transgenic animal studies involving disruption and overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones, local growth factors, as well as mechanical stress. In this review we describe findings from various genetic mouse models that pertain to the role of endocrine and local sources of IGF-I in the regulation of skeletal growth.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.