Evidence map›Paper›PMID 22544506›Full record

ArticleMaternal and child health journal2013

First trimester exposure to ambient air pollution, pregnancy complications and adverse birth outcomes in Allegheny County, PA.

Pei-Chen Lee, James M Roberts, Janet M Catov, Evelyn O Talbott, Beate Ritz

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Maternal and child health journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02786420 (Imaging Innovations for Placental Assessment in Response to Environmental Pollution), which is not on this map. Cited by 105 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 14 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02786420 completednot on this mapstarted 2015, after this paper: background citation

Imaging Innovations for Placental Assessment in Response to Environmental Pollution

TypeobservationalSponsorUniversity of California, Los AngelesRan2015 to 2020Enrolled199ConditionsPlacental Disease
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 14 syntheses or guidelines pooled it, 222 citations in OpenAlex.

  1. Pooled it
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  8. Maternal fine particulate matter (PMEnvironmental science and pollution research international · 2019
    Pooled it
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  10. Environmental contaminants and preeclampsia: a systematic literature review.Journal of toxicology and environmental health. Part B, Critical reviews · 2018
    Pooled it
  11. Pooled it
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  13. Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis.Environmental science and pollution research international · 2015
    Pooled it
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  15. Trial
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pei-Chen LeeDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. pel27@ucla.edu
James M Roberts
Janet M Catov
Evelyn O Talbott
Beate Ritz
University of Pittsburgh · USUniversity of California, Los Angeles · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Air Pollution and Adverse Birth OutcomesR01ES010960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R · 2001 to 2004
$921k
NCATS NIH HHS UL1 TR000005NIEHS NIH HHS R01 ES010960
6 · The paper itself

Abstract

Despite numerous studies of air pollution and adverse birth outcomes, few studies have investigated preeclampsia and gestational hypertension, two pregnancy disorders with serious consequences for both mother and infant. Relying on hospital birth records, we conducted a cohort study identifying 34,705 singleton births delivered at Magee-Women's Hospital in Pittsburgh, PA between 1997 and 2002. Particle (<10 μm-PM10; <2.5 μm-PM2.5) and ozone (O3) exposure concentrations in the first trimester of pregnancy were estimated using the space-time ordinary Kriging interpolation method. We employed multiple logistic regression estimate associations between first trimester exposures and preeclampsia, gestational hypertension, preterm delivery, and small for gestational age (SGA) infants. PM2.5 and O3 exposures were associated with preeclampsia (adjusted OR = 1.15, 95% CI = 0.96-1.39 per 4.0 μg/m(3) increase in PM2.5; adjusted OR = 1.12, 95% CI = 0.89-1.42 per 16.8 ppb increase in O3), gestational hypertension (for PM2.5 OR = 1.11, 95 % CI = 1.00-1.23; for O3 OR = 1.12, 95 % CI = 0.97-1.29), and preterm delivery (for PM2.5 ORs = 1.10, 95% CI = 1.01-1.20; for O3 ORs = 1.23, 95% CI = 1.01-1.50). Smaller 5-8 % increases in risk were also observed for PM10 with gestational hypertension and SGA, but not preeclampsia. Our data suggest that first trimester exposure to particles, mostly PM2.5, and ozone, may increase the risk of developing preeclampsia and gestational hypertension, as well as preterm delivery and SGA.

Indexed as

AdultAir PollutantsAir PollutionCohort StudiesFemaleHumansHypertension, Pregnancy-InducedInfant, NewbornInfant, Small for Gestational AgeLogistic ModelsMaternal ExposureOdds RatioParticulate MatterPennsylvaniaPopulation SurveillancePregnancyAir PollutantsParticulate Matter

Identifiers

PMID22544506
PMCPMC3636771
OpenAlexW2097772164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.