ArticleInternational archives of occupational and environmental health2013
Is specific IgE antibody analysis feasible for the diagnosis of methylenediphenyl diisocyanate-induced occupational asthma?
Article in International archives of occupational and environmental health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Lung Gene Expression Suggests Roles for Interferon-Stimulated Genes and Adenosine Deaminase Acting against RNA-1 in Pathologic Responses to Diisocyanate.Chemical research in toxicology · 2024Article
- Progress in Occupational Asthma.International journal of environmental research and public health · 2020Review
- Molecular Characterization and Experimental Utility of Monoclonal Antibodies with Specificity for Aliphatic Di- and Polyisocyanates.Monoclonal antibodies in immunodiagnosis and immunotherapy · 2020Article
- Review
- Dilysine-Methylene Diphenyl Diisocyanate (MDI), a Urine Biomarker of MDI Exposure?Chemical research in toxicology · 2019Article
- Circulating miRs-183-5p, -206-3p and -381-3p may serve as novel biomarkers for 4,4'-methylene diphenyl diisocyanate exposure.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2019Article
- Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway.Toxicology research · 2018Review
- Opportunities and obstacles in translating evidence to policy in occupational asthma.Annals of epidemiology · 2018Article
- Usefulness of Biomarkers in Work-Related Airway Disease.Current treatment options in allergy · 2017Review
- The influence of diisocyanate antigen preparation methodology on monoclonal and serum antibody recognition.Journal of occupational and environmental hygiene · 2016Article
- Career Advice for Young Allergy Patients.Deutsches Arzteblatt international · 2016Review
- Characterization and comparative analysis of 2,4-toluene diisocyanate and 1,6-hexamethylene diisocyanate haptenated human serum albumin and hemoglobin.Journal of immunological methods · 2016Article
- Spotlight on the diagnosis of extrinsic allergic alveolitis (hypersensitivity pneumonitis).Journal of occupational medicine and toxicology (London, England) · 2015Article
- Biological and genetic markers in occupational asthma.Current allergy and asthma reports · 2015Review
- Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin.Analytical biochemistry · 2013Article
- Diagnostic approach in cases with suspected work-related asthma.Journal of occupational medicine and toxicology (London, England) · 2013Article
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Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly recognition improves the prognosis of isocyanate asthma. A major unanswered question is whether IgE-dependent mechanisms are of diagnostic value? Our objective was to appraise serological methods using various methylenediphenyl diisocyanate (MDI)-albumin conjugates and weigh up the data versus the outcome of standardized comprehensive clinical diagnostics to evaluate the viability of immunological analysis in supportive MDI-asthma diagnosis (OAI).
methodsSpecific IgE (sIgE) and IgG (sIgG) binding was measured with fluorescence enzyme immunoassay in 43 study subjects (using conjugates prepared in-vapor, in-solution and commercial preparations). The differential clinical diagnosis included standardized measurement of pulmonary function, non-specific bronchial hyper-responsiveness, specific MDI-prick test (MDI-SPT) and specific inhalation challenge (MDI-SIC).
resultsDetailed diagnostic scheme allows the differential OAI and MDI-induced hypersensitivity pneumonitis (PI). The presumed OAI diagnoses were confirmed in 84 % (45 % cases having demonstrable sIgE antibodies) with RR 5.7, P > 0.001, when OAI diagnosis is correlated with MDI-SIC/MDI-SPT (RR 1.28 for MDI-SIC alone); sIgG antibodies were clinically relevant for PI and not for the OA diagnosis. MDI-specific IgE data generated with commercial ImmunoCAP preparations show high correlation with our in-vapor generated MDI conjugates.
conclusionsIsocyanate-specific IgE antibodies are not always detectable but their presence is strongly predictive of OAI and supportive for the diagnosis. MDI-SPT can be a valuable parameter differentiating OAI and PI. We have confirmed and extended published data showing that isocyanate-albumin conjugates perform better in specific antibody assays when prepared with volatile phase formulations and would like to stress additionally the necessity for further refinements and standardization in clinical diagnostics procedures.
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