ArticleJournal of neurology2012
Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany--a nationwide population-based study in children and adults.
Article in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety of Levetiracetam in Paediatrics: A Systematic Review.PloS one · 2016Pooled it
- Initial Monotherapy and Further Anti-seizure Medication Regimens in Adult Patients with Epilepsy: A Population-Based, Longitudinal, Retrospective Analysis of German Prescription Data.Neurology and therapy · 2026Article
- [Epilepsy and pregnancy].Der Nervenarzt · 2024Review
- Hepatitis C virus treatment with glecaprevir and pibrentasvir in patients co-prescribed carbamazepine: Three case reports.World journal of gastrointestinal pharmacology and therapeutics · 2023Article
- Do Antiepileptic Drugs Change the Levels of Arginine Derivatives in Epileptic Children Treated with Polytherapy? The Results of a Case-Control Study.Children (Basel, Switzerland) · 2022Article
- Pharmacovigilance in Pediatric Patients with Epilepsy Using Antiepileptic Drugs.International journal of environmental research and public health · 2022Article
- Serum Levels of Lipids and Selected Aminothiols in Epileptic Children-A Pilot Case-Control Study.Brain sciences · 2022Article
- Bright, but allergic and neurotic? A critical investigation of the "overexcitable genius" hypothesis.Frontiers in psychology · 2022Article
- Anti-seizure medication is not associated with an increased risk to develop cancer in epilepsy patients.Journal of neurology · 2021Article
- Epilepsy lifetime prevalence in Iran: a large population- based national survey.Scientific reports · 2021Article
- [Inpatient treatment costs, cost-driving factors and potential reimbursement problems due to epileptic seizure-related injuries and fractures].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Article
- The impact of the coronavirus disease (COVID-19) pandemic on outpatient epilepsy care: An analysis of physician practices in Germany.Epilepsy & behavior : E&B · 2021Article
- Medication adherence in multiple sclerosis as a potential model for other chronic diseases: a population-based cohort study.BMJ open · 2021Article
- Anti-seizure Medication Prescription in Adult Outpatients With Epilepsy in China, 2013-2018.Frontiers in neurology · 2021Article
- Patterns of anticonvulsant use and adverse drug events in older adults.Pharmacoepidemiology and drug safety · 2021Article
- SARS-CoV-2-related rapid reorganization of an epilepsy outpatient clinic from personal appointments to telemedicine services: A German single-center experience.Epilepsy & behavior : E&B · 2020Article
- Observational
- [Sudden unexpected death in epilepsy (SUDEP) : Epidemiology, cardiac and other risk factors].Herzschrittmachertherapie & Elektrophysiologie · 2019Review
- Understanding the burden of focal epilepsy as a function of seizure frequency in the United States, Europe, and Brazil.Epilepsia open · 2017Article
- Anti-epileptic drug utilisation in paediatrics: a systematic review.BMJ paediatrics open · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nationwide analyses of drug use can provide a prevalence estimate of the underlying disease and can help in understanding the characteristics of treatment. This study aimed for such analyses regarding the utilization of antiepileptic drugs (AED) for epilepsy in Germany. In 2009, all 4,115,705 AED prescriptions of all German patients with statutory health insurance (70,011,508 persons) were retrospectively analyzed. The IMS(®) LRx database served as data source, which accesses nationwide pharmacy data centers processing all German prescription data. To establish the age and sex-specific percentage of patients taking AED because of epilepsy, we used a second database, Disease Analyzer(®), which covered a representative sample of the German population (7.2 million patients) and contained ICD10 codes alongside with prescription data. The period prevalence of patients taking AED because of epilepsy was 9.1/1,000 (children/adolescents: 5.2/1,000; elderly: 12.5/1,000). Of the patients, 83.1 % took at least one of four AED: valproate (29.8 %), carbamazepine (26.4 %), lamotrigine (21.4 %), and levetiracetam (16.9 %). Oxcarbazepine and sultiame were popular with pediatricians. Elderly patients frequently received phenytoin and primidone. More than half of the patients were treated by family physicians; 68 % took AED in monotherapy and 7.9 % received >2 AED (children/adolescents: 12.5 %). The costs for AED prescribed for epilepsy amounted to €285.1 Mio (median AED costs/patient: €158/a). The German 2009 prevalence of epileptic patients taking AED was 9.1/1,000. Family physicians cared for the majority of patients. Prevalence and prescribing patterns changed with age. Costs of AED against epilepsy added up to 1 % of total medication costs in Germany.
Indexed as
Identifiers
22544296What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.