ArticleJournal of bacteriology2012
The divergent AmoC3 subunit of ammonia monooxygenase functions as part of a stress response system in Nitrosomonas europaea.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Ammonia monooxygenase: a work in progress.Chemical science · 2026Review
- Elevated temperature simulating heatwaves restructures active nitrifying communities and associated viruses in tidal flats and agricultural soils.The ISME journal · 2026Article
- Targeted assembly recovers high ammonia monooxygenase diversity in mudflat intertides.mSystems · 2025Article
- Diversity and characterization of the ammonia-oxidizing bacteria responsible for nitrification in tea field soils.Scientific reports · 2025Article
- Growth of soil ammonia-oxidizing archaea on air-exposed solid surface.ISME communications · 2024Article
- Transcriptomic Insights into Archaeal Nitrification in the Amundsen Sea Polynya, Antarctica.Journal of microbiology (Seoul, Korea) · 2023Article
- Unexpected complexity of the ammonia monooxygenase in archaea.The ISME journal · 2023Article
- Genome wide transcriptomic analysis of the soil ammonia oxidizing archaeon Nitrososphaera viennensis upon exposure to copper limitation.The ISME journal · 2020Article
- Genomic Insights of "Frontiers in microbiology · 2020Article
- Transcriptome Analysis of the Ammonia-Oxidizing Bacterium Nitrosomonas mobilis Ms1 Reveals Division of Labor between Aggregates and Free-living Cells.Microbes and environments · 2020Article
- Complete nitrification: insights into the ecophysiology of comammox Nitrospira.Applied microbiology and biotechnology · 2019Review
- Characterization of a long overlooked copper protein from methane- and ammonia-oxidizing bacteria.Nature communications · 2018Article
- Stress response of a marine ammonia-oxidizing archaeon informs physiological status of environmental populations.The ISME journal · 2018Article
- Evolutionary History of Copper Membrane Monooxygenases.Frontiers in microbiology · 2018Article
- Comparative Proteomics of Three Species of Ammonia-Oxidizing Bacteria.Frontiers in microbiology · 2018Article
- Ammonia-oxidising archaea living at low pH: Insights from comparative genomics.Environmental microbiology · 2017Article
- Proteomics and comparative genomics of Nitrososphaera viennensis reveal the core genome and adaptations of archaeal ammonia oxidizers.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Comparison of Nitrogen Oxide Metabolism among Diverse Ammonia-Oxidizing Bacteria.Frontiers in microbiology · 2016Article
- Complete nitrification by a single microorganism.Nature · 2015Article
- Complete nitrification by Nitrospira bacteria.Nature · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ammonia monooxygenase of chemolithotrophic ammonia-oxidizing bacteria (AOB) catalyzes the first step in ammonia oxidation by converting ammonia to hydroxylamine. The monooxygenase of Nitrosomonas europaea is encoded by two nearly identical operon copies (amoCAB(1,2)). Several AOB, including N. europaea, also possess a divergent monocistronic copy of amoC (amoC(3)) of unknown function. Previous work suggested a possible functional role for amoC(3) as part of the σ(E) stress response regulon during the recovery of N. europaea from extended ammonia starvation, thus indicating its importance during the exit of cells from starvation. We here used global transcription analysis to show that expression of amoC(3) is part of a general poststarvation cellular response system in N. europaea. We also found that amoC(3) is required for an efficient response to some stress conditions, as deleting this gene impaired growth at elevated temperatures and recovery following starvation under high oxygen tensions. Deletion of the σ(32) global stress response regulator demonstrated that the heat shock regulon plays a significant role in mediating the recovery of N. europaea from starvation. These findings provide the first described phenotype associated with the divergent AmoC(3) subunit which appears to function as a stress-responsive subunit capable of maintaining ammonia oxidation activity under stress conditions. While this study was limited to starvation and heat shock, it is possible that the AmoC(3) subunit may be responsive to other membrane stressors (e.g., solvent or osmotic shocks) that are prevalent in the environments of AOB.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.