ArticleApplied and environmental microbiology2012
Detecting genetic introgression: high levels of intersubspecific recombination found in Xylella fastidiosa in Brazil.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The hidden life ofApplied and environmental microbiology · 2025Article
- Amylase-associated genetic pattern inApplied and environmental microbiology · 2024Article
- Parallel host shifts in a bacterial plant pathogen suggest independent genetic solutions.Molecular plant pathology · 2023Article
- The Multifaceted Role of Homologous Recombination in a Fastidious Bacterial Plant Pathogen.Applied and environmental microbiology · 2023Article
- Complete functional analysis of type IV pilus components of a reemergent plant pathogen reveals neofunctionalization of paralog genes.PLoS pathogens · 2023Article
- Suspicions of two bridgehead invasions of Xylella fastidiosa subsp. multiplex in France.Communications biology · 2023Article
- Genetic differentiation ofMicrobial genomics · 2021Article
- Allopatric Plant Pathogen Population Divergence following Disease Emergence.Applied and environmental microbiology · 2021Article
- Phenotypic Characterization and Transformation Attempts Reveal Peculiar Traits ofMicroorganisms · 2020Article
- Impacts of local population history and ecology on the evolution of a globally dispersed pathogen.BMC genomics · 2020Article
- Genome-Scale Investigation of the Metabolic Determinants Generating Bacterial Fastidious Growth.mSystems · 2020Article
- Emergence of a Plant Pathogen in Europe Associated with Multiple Intercontinental Introductions.Applied and environmental microbiology · 2020Article
- Patterns of inter- and intrasubspecific homologous recombination inform eco-evolutionary dynamics of Xylella fastidiosa.The ISME journal · 2019Article
- Genomic Diversity and Recombination among Xylella fastidiosa Subspecies.Applied and environmental microbiology · 2019Article
- Xylella fastidiosa: climate suitability of European continent.Scientific reports · 2019Article
- Identification of genetic relationships and subspecies signatures in Xylella fastidiosa.BMC genomics · 2019Article
- Using insects to detect, monitor and predict the distribution of Xylella fastidiosa: a case study in Corsica.Scientific reports · 2018Article
- Population genomics of bacterial host adaptation.Nature reviews. Genetics · 2018Review
- Updated pest categorisation ofEFSA journal. European Food Safety Authority · 2018Article
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4 authors.
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Abstract
Documenting the role of novel mutation versus homologous recombination in bacterial evolution, and especially in the invasion of new hosts, is central to understanding the long-term dynamics of pathogenic bacteria. We used multilocus sequence typing (MLST) to study this issue in Xylella fastidiosa subsp. pauca from Brazil, a bacterium causing citrus variegated chlorosis (CVC) and coffee leaf scorch (CLS). All 55 citrus isolates typed (plus one coffee isolate) defined three similar sequence types (STs) dominated by ST11 (85%), while the remaining 22 coffee isolates defined two STs, mainly ST16 (74%). This low level of variation masked unusually large allelic differences (>1% divergence with no intermediates) at five loci (leuA, petC, malF, cysG, and holC). We developed an introgression test to detect whether these large differences were due to introgression via homologous recombination from another X. fastidiosa subspecies. Using additional sequencing around these loci, we established that the seven randomly chosen MLST targets contained seven regions of introgression totaling 2,172 bp of 4,161 bp (52%), only 409 bp (10%) of which were detected by other recombination tests. This high level of introgression suggests the hypothesis that X. fastidiosa subsp. pauca became pathogenic on citrus and coffee (crops cultivated in Brazil for several hundred years) only recently after it gained genetic variation via intersubspecific recombination, facilitating a switch from native hosts. A candidate donor is the subspecies infecting plum in the region since 1935 (possibly X. fastidiosa subsp. multiplex). This hypothesis predicts that nonrecombinant native X. fastidiosa subsp. pauca (not yet isolated) does not cause disease in citrus or coffee.
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