ArticleThe EMBO journal2012
Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 160 citations in OpenAlex.
- Article
- Article
- Regeneration leads to global tissue rejuvenation in aging sexual planarians.Nature aging · 2025Article
- Chromatin remodeling protein BPTF mediates chromatin accessibility at gene promoters in planarian stem cells.BMC genomics · 2025Article
- Stem cells (neoblasts) and positional information jointly dominate regeneration in planarians.Heliyon · 2025Review
- Mining differentially expressed genes during paratomy in the transcriptome of the flatworm Stenostomum leucops.Scientific reports · 2024Article
- Mining of potentially stem cell-related miRNAs in planarians.Molecular biology reports · 2024Review
- Annelid adult cell type diversity and their pluripotent cellular origins.Nature communications · 2024Article
- Purification of Planarian Stem Cells Using a Draq5-Based FACS Approach.Methods in molecular biology (Clifton, N.J.) · 2024Article
- The Information Theory of Aging.Nature aging · 2023Review
- The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.BMC biology · 2023Article
- Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy.Science advances · 2023Article
- Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth.Current biology : CB · 2023Article
- Review
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- CTR9 drives osteochondral lineage differentiation of human mesenchymal stem cells via epigenetic regulation of BMP-2 signaling.Science advances · 2022Article
- Distinct patterns of gene expression during regeneration and asexual reproduction in the annelid Pristina leidyi.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2022Article
- Single-cell transcriptomics in planaria: new tools allow new insights into cellular and evolutionary features.Biochemical Society transactions · 2022Review
- Cell repertoire and proliferation of germinative cells of the model cestodeParasitology · 2022Article
- Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Freshwater planaria possess extreme regeneration capabilities mediated by abundant, pluripotent stem cells (neoblasts) in adult animals. Although planaria emerged as an attractive in vivo model system for stem cell biology, gene expression in neoblasts has not been profiled comprehensively and it is unknown how molecular mechanisms for pluripotency in neoblasts relate to those in mammalian embryonic stem cells (ESCs). We purified neoblasts and quantified mRNA and protein expression by sequencing and shotgun proteomics. We identified ∼4000 genes specifically expressed in neoblasts, including all ∼30 known neoblast markers. Genes important for pluripotency in ESCs, including regulators as well as targets of OCT4, were well conserved and upregulated in neoblasts. We found conserved expression of epigenetic regulators and demonstrated their requirement for planarian regeneration by knockdown experiments. Post-transcriptional regulatory genes characteristic for germ cells were also enriched in neoblasts, suggesting the existence of a common ancestral state of germ cells and ESCs. We conclude that molecular determinants of pluripotency are conserved throughout evolution and that planaria are an informative model system for human stem cell biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.