Trial reportInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2013
Effects of couple interactions and relationship quality on plasma oxytocin and cardiovascular reactivity: empirical findings and methodological considerations.
Trial report in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Endogenous oxytocin and human social interactions: A systematic review and meta-analysis.Psychological bulletinPooled it
- The Role of Oxytocin and Sex in Analgesic Placebo-Response: Exploratory Analysis from a Sham Randomized Clinical Trial in Chronic Back-Pain Patients.Journal of clinical medicine · 2025Article
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- Advances in human oxytocin measurement: challenges and proposed solutions.Molecular psychiatry · 2023Review
- Partner's Perceived Social Support Influences Their Spouse's Inflammation: An Actor-Partner Analysis.International journal of environmental research and public health · 2022Article
- The link between oxytocin plasma levels and observed communication behaviors during sexual and nonsexual couple discussions: An exploratory study.Psychoneuroendocrinology · 2021Article
- Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- Sleep-Wake Concordance in Couples Is Inversely Associated With Cardiovascular Disease Risk Markers.Sleep · 2017Article
- Evidence for a role of the oxytocin system, indexed by genetic variation in CD38, in the social bonding effects of expressed gratitude.Social cognitive and affective neuroscience · 2014Article
- Negative social interactions and incident hypertension among older adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014Article
- Intranasal administration of oxytocin: behavioral and clinical effects, a review.Neuroscience and biobehavioral reviews · 2013Article
- Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.Frontiers in neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Cardiovascular reactivity is a potential mechanism underlying associations of close relationship quality with cardiovascular disease. Two models describe oxytocin as another mechanism. The "calm and connect" model posits an association between positive relationship experiences and oxytocin levels and responses, whereas the "tend and befriend" model emphasizes the effects of negative relationship experiences in evoking oxytocin release. In this study of 180 younger couples, relationship quality had a small, marginally significant inverse association with plasma oxytocin levels, and neither positive nor negative couple interactions evoked change in plasma oxytocin. Negative couple interactions evoked significant cardiovascular reactivity, especially among women. Hence, in the largest study of these issues to date, there was little support for key tenets of the "calm and connect" model, and only very modest support for the "tend and befriend" model. However, findings were consistent with the view that CVR contributes to the effects of relationship difficulties on health.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.