ArticleGenetics2012
Establishment of new mutations in changing environments.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Causes of heterozygosity excess: The case of Mexican populations ofPlant diversity · 2025Article
- Temporal Pattern of the Emergence of a Mutant Virus Escaping Cross-Immunity and Stochastic Extinction Within a Host.Bulletin of mathematical biology · 2023Article
- Evolutionary rescue in a fluctuating environment: periodic versus quasi-periodic environmental changes.Proceedings. Biological sciences · 2023Article
- Article
- Article
- Environmental fluctuations can promote evolutionary rescue in high-extinction-risk scenarios.Proceedings. Biological sciences · 2020Article
- Surfing on the seascape: Adaptation in a changing environment.Evolution; international journal of organic evolution · 2019Article
- Phenotypic lag and population extinction in the moving-optimum model: insights from a small-jumps limit.Journal of mathematical biology · 2018Article
- Article
- Fixation probability of a beneficial mutation conferring decreased generation time in changing environments.BMC systems biology · 2018Article
- Adaptations of an RNA virus to increasing thermal stress.PloS one · 2017Article
- Adaptation to Temporally Fluctuating Environments by the Evolution of Maternal Effects.PLoS biology · 2016Article
- GNBP domain of Anopheles darlingi: are polymorphic inversions and gene variation related to adaptive evolution?Genetica · 2016Article
- Evolution in changing environments: modifiers of mutation, recombination, and migration.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Evolutionary rescue: an emerging focus at the intersection between ecology and evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Evolutionary rescue by beneficial mutations in environments that change in space and time.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding adaptation in changing environments is an important topic in evolutionary genetics, especially in the light of climatic and environmental change. In this work, we study one of the most fundamental aspects of the genetics of adaptation in changing environments: the establishment of new beneficial mutations. We use the framework of time-dependent branching processes to derive simple approximations for the establishment probability of new mutations assuming that temporal changes in the offspring distribution are small. This approach allows us to generalize Haldane's classic result for the fixation probability in a constant environment to arbitrary patterns of temporal change in selection coefficients. Under weak selection, the only aspect of temporal variation that enters the probability of establishment is a weighted average of selection coefficients. These weights quantify how much earlier generations contribute to determining the establishment probability compared to later generations. We apply our results to several biologically interesting cases such as selection coefficients that change in consistent, periodic, and random ways and to changing population sizes. Comparison with exact results shows that the approximation is very accurate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.