ArticleCancer epidemiology2012
Androgen metabolism and JAK/STAT pathway genes and prostate cancer risk.
Article in Cancer epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- The Role of Cytochrome P450 Holoenzyme Metabolism in the Origin of Neuropathologies.International journal of molecular sciences · 2026Review
- Deciphering 17-β-hydroxysteroid dehydrogenase 4: from molecular insights to cancer therapeutics.Cancer cell international · 2025Review
- Review
- STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan.Gene reports · 2024Article
- FAM64A is an androgen receptor-regulated feedback tumor promoter in prostate cancer.Cell death & disease · 2021Article
- SULT genetic polymorphisms: physiological, pharmacological and clinical implications.Expert opinion on drug metabolism & toxicology · 2021Review
- SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.Oncotarget · 2020Article
- Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.PloS one · 2020Article
- STAT3 and STAT5A are potential therapeutic targets in castration-resistant prostate cancer.Oncotarget · 2017Article
- Article
- Functional networks inference from rule-based machine learning models.BioData mining · 2016Article
- Prostate Cancer Stem-like Cells Contribute to the Development of Castration-Resistant Prostate Cancer.Cancers · 2015Review
- MAPK and JAK/STAT pathways targeted by miR-23a and miR-23b in prostate cancer: computational and in vitro approaches.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes.International journal of clinical and experimental pathology · 2015Article
- Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes.Disease markers · 2015Review
- Polymorphisms in immune mediators associate with risk of cervical cancer.Gynecologic oncology · 2014Article
- Sex hormone pathway gene polymorphisms are associated with risk of advanced hepatitis C-related liver disease in males.International journal of molecular epidemiology and genetics · 2014Article
- Integrative genomic analysis for the discovery of biomarkers in prostate cancer.Biomarker insights · 2014Article
- RAMP1 is a direct NKX3.1 target gene up-regulated in prostate cancer that promotes tumorigenesis.The American journal of pathology · 2013Article
- Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundProstate cancer (PC) is the most frequently diagnosed solid tumor in U.S. men. Genome-wide association studies (GWAS) have identified over 40 risk-associated single nucleotide polymorphisms (SNPs), including variants in androgen pathway genes (e.g., KLK3 and AR). Androgens are important in PC and genes involved in this pathway are therefore candidates for conferring susceptibility to PC.
methodsIn this hypothesis-testing study, we evaluated PC risk in association with SNPs in 22 candidate genes involved in androgen metabolism or interactions with the androgen receptor (AR). A total of 187 SNPs were genotyped in 1458 cases and 1351 age-matched controls from a population-based study. PC risk was estimated using adjusted unconditional logistic regression and multinomial regression models.
resultsSingle SNP analyses showed evidence (p < 0.05) for associations with 14 SNPs in 9 genes: NKX3.1, HSD17B3, AKR1C3, SULT2A1, CYP17A1, KLK3, JAK2, NCOA4 and STAT3. The most significant result was observed for rs2253502 in HSD17B3 (odds ratio, OR = 0.57, 95% CI: 0.39-0.84). In addition, five SNPs in four genes (CYP17A1, HSD17B4, NCOA4, and SULT2A1) were associated with more aggressive disease (p < 0.01).
conclusionsOur results replicate previously reported associations for SNPs in CYP17A1, HSD17B3, ARK1C3, NKX3.1, NCOA4 and KLK3. In addition, novel associations were observed for SNPs in JAK2, HSD17B4, and SULT2A1. These results will require replication in larger studies.
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